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Gene Expression Data
Assay Details
Assay
Reference: J:133765 Makita T, et al., Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10;452(7188):759-63
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7343794
Gene symbol: Th
Gene name: tyrosine hydroxylase
Antibody: Anti-TH
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 1d: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 1d Expression was detected in superior cervical ganglion axons that extend cranially along the primitive internal carotid artery.

Specimen 1g: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 1g Expression was detected in superior cervical ganglion axons that extend cranially along the primitive internal carotid artery. No sympathetic axon projections were found along either nascent external carotid arteries or the third arch arteries.

Specimen 1j: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 1j Expression was detected in superior cervical ganglion axons that extend cranially along the internal carotid artery.

Specimen 1m: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 1m Expression was detected on sympathetic neuron axons.

Specimen 1q: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 1q Expression was detected on superior cervical ganglion axonal projections associated with the internal carotid artery.

Specimen 1t: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 1t Expression was detected on superior cervical ganglion axonal projections associated with the external carotid artery.

Specimen 2n: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 2n Expression was detected in the rostral end of the sympathetic chain.

Specimen 2q: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present Regionally restricted 2q Expression was detected in superior cervical ganglion.

Specimen 2t: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present 2t

Specimen 4a: embryonic day 13.5 (more )
Note: Section from the cochlea-pituitary level.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4a Expression was detected on the rostral projection from the superior cervical ganglion along the internal carotid artery.

Specimen 4b: embryonic day 13.5 (more )
Note: Section from the level of the branch of the stapedial artery from the internal carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4b Expression in the superior cervical ganglion and the initial projection to the internal carotid artery.

Specimen 4c: embryonic day 13.5 (more )
Note: Section from a level immediately above the bifurcation of the external and internal carotid arteries from the common carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4c Expression in the superior cervical ganglion and axonal projections to the external carotid artery.

Specimen 4g: embryonic day 13.5; Ednratm1Ywa/Ednratm1Ywa (more )
Note: Section from the cochlea-pituitary level.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present 4g Normal expression was noted in the axonal projections to the internal carotid artery.

Specimen 4h: embryonic day 13.5; Ednratm1Ywa/Ednratm1Ywa (more )
Note: Section from the level of the branch of the stapedial artery from the internal carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present 4h Normal expression was noted in the superior cervical ganglion.

Specimen 4i: embryonic day 13.5; Ednratm1Ywa/Ednratm1Ywa (more )
Note: Section from a level immediately above the bifurcation of the external and internal carotid arteries from the common carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4i Expression in the superior cervical ganglion. However, there were no axonal projections along the external carotid artery.

Specimen 4m: embryonic day 13.5 (more )
Note: Section from the cochlea-pituitary level.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4m Expression was detected on the rostral projection from the superior cervical ganglion along the internal carotid artery.

Specimen 4n: embryonic day 13.5 (more )
Note: Section from the level of the branch of the stapedial artery from the internal carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4n Expression in the superior cervical ganglion and the initial projection to the internal carotid artery.

Specimen 4o: embryonic day 13.5 (more )
Note: Section from a level immediately above the bifurcation of the external and internal carotid arteries from the common carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4o Expression in the superior cervical ganglion and axonal projections to the external carotid artery.

Specimen 4p: embryonic day 13.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Section from the cochlea-pituitary level.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present 4p Normal expression was noted in the axonal projections to the internal carotid artery.

Specimen 4q: embryonic day 13.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Section from the level of the branch of the stapedial artery from the internal carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present 4q Normal expression was noted in the superior cervical ganglion.

Specimen 4r: embryonic day 13.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Section from a level immediately above the bifurcation of the external and internal carotid arteries from the common carotid artery.
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present Regionally restricted 4r Expression in the superior cervical ganglion. However, there were no axonal projections along the external carotid artery.

Specimen S1d: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present S1d

Specimen S1g: embryonic day 11.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS20: cervical ganglion Present S1g

Specimen S1j: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present S1j

Specimen S1m: embryonic day 12.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present S1m

Specimen S1q: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present S1q Expression was detected in superior cervical ganglion axons that extend along the internal carotid artery.

Specimen S1t: embryonic day 13.5; Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: superior cervical ganglion Present S1t Expression was detected in superior cervical ganglion axons that extend along the external and internal carotid arteries.

Specimen S5a: embryonic day 15.5 (more )
Note: Level of the ophthalmic artery branching into the lacrimal arteries.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5a Expression was detected in superior cervical ganglion axonal projections.

Specimen S5b: embryonic day 15.5 (more )
Note: Level of the internal carotid artery branching to form the ophthalmic artery which is directed to the eye.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5b Expression was detected in superior cervical ganglion axonal projections along the internal carotid artery.

Specimen S5c: embryonic day 15.5 (more )
Note: Level of the internal carotid artery branching to form the stapedial artery.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5c Expression was detected in superior cervical ganglion axonal projections along the internal carotid artery.

Specimen S5d: embryonic day 15.5 (more )
Note: Level of the carotid bifurcation, with sympathetic axons from the SCG projecting along the external carotid artery.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5d Expression was detected in superior cervical ganglion axonal projections along the internal and external carotid arteries.

Specimen S5e: embryonic day 15.5 (more )
Note: Level of the external carotid artery where it branches to form the superficial temporal artery.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5e Expression was detected in superior cervical ganglion axonal projections along the external carotid artery.

Specimen S5f: embryonic day 15.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Level of the ophthalmic artery branching into the lacrimal arteries.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5f Normal expression was detected in superior cervical ganglion axonal projections along the internal carotid artery.

Specimen S5g: embryonic day 15.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Level of the internal carotid artery branching to form the ophthalmic artery which is directed to the eye.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5g Normal expression was detected in superior cervical ganglion axonal projections along the internal carotid artery.

Specimen S5h: embryonic day 15.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Level of the internal carotid artery branching to form the stapedial artery.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5h Normal expression was detected in superior cervical ganglion axonal projections along the internal carotid artery.

Specimen S5i: embryonic day 15.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Level of the carotid bifurcation, with sympathetic axons from the SCG projecting along the external carotid artery.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5i Normal expression was detected in superior cervical ganglion axonal projections along the internal carotid artery. However, mutants demonstrated markedly deficient projections along the external carotid artery.

Specimen S5j: embryonic day 15.5; Edn3tm1Ywa/Edn3tm1Ywa (more )
Note: Level of the external carotid artery where it branches to form the superficial temporal artery.
Structure Level Pattern Image Note
TS23: superior cervical ganglion Present Regionally restricted S5j Mutants demonstrated markedly deficient projections along the external carotid artery.


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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory