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Gene Expression Data
Assay Details
Assay
Reference: J:177214 Rinehart J, et al., WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem. 2011 Aug 26;286(34):30171-80
Assay type: RNA in situ
MGI Accession ID: MGI:7343766
Gene symbol: Wnk2
Gene name: WNK lysine deficient protein kinase 2
Probe: Wnk2 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1 E14.5: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex intermediate zone neuron Strong 1_E14.5 Expression is in post-mitotic neurons.
TS22: cortical plate neuron Strong 1_E14.5 Expression is in post-mitotic neurons.
TS22: cerebellum Present 1_E14.5
TS22: thalamus Present 1_E14.5
TS22: midbrain Present Regionally restricted 1_E14.5 Expression is dorsal.
TS22: basal ganglia Weak 1_E14.5
TS22: brain ventricular layer Weak 1_E14.5
Specimen 1 adult top: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: cortical layer I neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer I pyramidal neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer II neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer II pyramidal neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer III neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer III pyramidal neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer IV neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer IV pyramidal neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer V neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer V pyramidal neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer VI neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: cortical layer VI pyramidal neuron Present 1_adult brain top right Strongest expression is in pyramidal neurons.
TS28: hippocampus Present 1_adult brain top right
TS28: main olfactory bulb Present 1_adult brain top right
TS28: telencephalon septum Present 1_adult brain top right
TS28: dorsal thalamus Present Non-Uniform 1_adult brain top right There are lower levels in the posterior thalamus.
TS28: hypothalamus Weak 1_adult brain top right
TS28: basal ganglia Absent 1_adult brain top right
Specimen 1 adult bottom: postnatal adult (more )
Structure Level Pattern Image Note
TS28: deep cerebellar nucleus Strong 1_adult brain bottom left
TS28: cerebellum Present 1_adult brain bottom left
Specimen 1 kidney: postnatal adult (more )
Structure Level Pattern Image Note
TS28: metanephros Absent 1_adult kidney WNK2
Specimen not shown E14.5: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: forebrain neuron Present Expression is in differentiating neurons.
TS22: hindbrain neuron Present Expression is in differentiating neurons.
Specimen not shown E15.5: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: forebrain neuron Present Expression is in differentiating neurons.
TS23: hindbrain neuron Present Expression is in differentiating neurons.
TS23: midbrain neuron Present Expression is in differentiating neurons.
TS23: basal ganglia Weak
TS23: brain ventricular layer Weak
Specimen 2 SMI-32: embryonic day 14.5 (more )
Note: Double labeled: blue - Wnk2; brown - Nefh (assay MGI:7343858).
Structure Cell Type Level Pattern Image Note
TS22: neocortex pyramidal neuron Present 2_SMI-32
Specimen 2 GFAP: embryonic day 14.5 (more )
Note: Double labeled: blue - Wnk2; brown - Gfap (assay MGI:7343779).
Structure Cell Type Level Pattern Image Note
TS22: neocortex neuron Present 2_GFAP
TS22: neocortex astrocyte Absent 2_GFAP
Specimen 2 Calbindin: embryonic day 14.5 (more )
Note: Double labeled: blue - Wnk2; brown - Calb1 (assay MGI:7343783).
Structure Cell Type Level Pattern Image Note
TS22: cerebellum layer Purkinje cell Present Regionally restricted 2_Calbindin Expression is in Purkinje cells.
Specimen S2 top: postnatal day 15 (more )
Structure Level Pattern Image Note
TS28: forebrain Present S2_WNK2 top
Specimen S2 bottom left: postnatal day 15 (more )
Structure Level Pattern Image Note
TS28: cerebellum Present S2_WNK2 bottom left
Specimen S2 bottom right: postnatal day 15 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present S2_WNK2 bottom right
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory