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Gene Expression Data
Assay Details
Assay
Reference: J:156467 Saxena A, et al., miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):87-91
Assay type: RNA in situ
MGI Accession ID: MGI:7341799
Gene symbol: Pitx2
Gene name: paired-like homeodomain transcription factor 2
Probe: Pitx2c probe5
Probe preparation: Antisense RNA
Results
Specimen 2A: embryonic day 10.25; Dicer1tm1Bdh/Dicer1tm1Bdh (more )
Structure Level Pattern Image Note
TS17: outflow tract Present 2A
TS17: primitive ventricle Present 2A
Specimen 2B: embryonic day 10.25; Dicer1tm1Bdh/Dicer1tm1Bdh, Nkx2-5tm2(cre)Rph/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: outflow tract Present 2B Increased expression compared with the control.
TS17: primitive ventricle Present 2B Increased expression in the ventricular wall adjacent to the outflow tract, compared with the control.
Specimen 2C: embryonic day 12.7; Dicer1tm1Bdh/Dicer1tm1Bdh (more )
Structure Level Pattern Image Note
TS20: heart ventricle Present 2C
TS20: outflow tract Present 2C
Specimen 2D: embryonic day 12.7; Dicer1tm1Bdh/Dicer1tm1Bdh, Nkx2-5tm2(cre)Rph/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: outflow tract Present 2D Increased expression compared with the control.
TS20: heart ventricle Present 2D Increased expression in the ventricular wall adjacent to the outflow tract, compared with the control.
Specimen 2E: embryonic day 13.0; Dicer1tm1Bdh/Dicer1tm1Bdh (more )
Structure Level Pattern Image Note
TS21: heart ventricle Present 2E
TS21: outflow tract Present 2E
Specimen 2F: embryonic day 13.0; Dicer1tm1Bdh/Dicer1tm1Bdh, Nkx2-5tm2(cre)Rph/Nkx2-5+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: heart ventricle Present 2F Increased expression in the ventricular wall adjacent to the outflow tract, compared with the control.
TS21: outflow tract Present 2F Increased expression compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory