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Gene Expression Data
Assay Details
Assay
Reference: J:219823 Rosin JM, et al., Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
Assay type: RNA in situ
MGI Accession ID: MGI:7336371
Gene symbol: Shox2
Gene name: SHOX homeobox 2
Probe: Shox2 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A/A': embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: diencephalon Present 1A
TS17: midbrain Present 1A
TS17: midbrain-hindbrain junction Present 1A
TS17: hindbrain Present 1A , 1A'
Specimen 1B/B': embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cerebellum primordium Present 1B
TS20: diencephalon Present 1B
TS20: hindbrain Present 1B
TS20: midbrain Present 1B
TS20: midbrain-hindbrain junction Present 1B , 1B' isthmus
TS20: metencephalon basal plate Present Regionally restricted 1B Expressed in prepontine hindbrain.
TS20: midbrain roof plate Present Regionally restricted 1B Expressed in the developing superior and inferior colliculi.
Specimen 1C/C': postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: forebrain-midbrain boundary region Present 1C
TS27: inferior colliculus Present 1C
TS27: superior colliculus Present 1C
TS27: cerebellar hemisphere Present Regionally restricted 1C , 1C' Expressed in a distinct layer of cells beneath the external granule layer.
Specimen 1D/D': postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: forebrain-midbrain boundary region Present 1D
TS27: inferior colliculus Present 1D
TS27: superior colliculus Present 1D
TS27: cerebellar hemisphere Present Regionally restricted 1D , 1D' Expressed in a distinct layer of cells beneath the external granule layer.
Specimen 1E: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 1E
Specimen S2C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain Present S2C mesencephalon
TS20: cerebellum primordium Present S2C
TS20: dorsal root ganglion Present S2C
TS20: forelimb Present S2C
Specimen S2D: embryonic day 12.5; Shox2tm1Ddu/Shox2tm1.1Ddu, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present S2D
TS20: forelimb Present S2D
TS20: cerebellum primordium Absent S2D
TS20: midbrain Absent S2D
Specimen S2E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain-hindbrain junction Present S2E isthmus
TS20: midbrain roof plate Present Regionally restricted S2E Expressed in the developing superior and inferior colliculi.
TS20: cerebellum primordium Present S2E
Specimen S2F: embryonic day 12.5; Shox2tm1Ddu/Shox2tm1.1Ddu, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebellum primordium Absent S2F
TS20: midbrain Absent S2F
TS20: midbrain-hindbrain junction Absent S2F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory