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Gene Expression Data
Assay Details
Assay
Reference: J:297683 Fernandez-Guerrero M, et al., Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30509-30519
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7335079
Gene symbol: Krt10
Gene name: keratin 10
Results
Specimen 2D wild type: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: eponychium Present Regionally restricted 2D Krt10 wild type Expression was detected in suprabasal epithelium.
Specimen 2D HoxC-/-: postnatal newborn; Hoxctm1Nogu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS27: eponychium Present Regionally restricted 2D Krt10 HoxC-/- Expression was detected in the suprabasal epithelium. Expression persisted in the epithelium of the mutant nail region.
TS27: hyponychium Present Regionally restricted 2D Krt10 HoxC-/- Expression was detected in the suprabasal epithelium. Expression persisted in the epithelium of the mutant nail region.
Specimen 4B: postnatal day 7; Hoxcem1Ddu/Hoxcem1Ddu (more )
Structure Level Pattern Image Note
TS28: eponychium Present 4B Krt10 Normal immunostaining was detected in the mutant.
Specimen 4C: postnatal day 7; Hoxcem2Ddu/Hoxcem2Ddu (more )
Structure Level Pattern Image Note
TS28: eponychium Present 4C Krt10
TS28: hyponychium Weak Regionally restricted 4C Krt10 Minor ectopic expression was detected in the nail matrix of the mutant.
Specimen 4D Newborn: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: eponychium Present 4D Newborn Krt10
Specimen 4E Newborn: postnatal newborn; Hoxcem3Ddu/Hoxcem3Ddu (more )
Structure Level Pattern Image Note
TS27: eponychium Present 4E Newborn Krt10
TS27: hyponychium Present Regionally restricted 4E Newborn Krt10 Abnormal expression remained in the proximal nail matrix.
Specimen 5B: postnatal newborn; Hoxcem3Ddu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS27: eponychium Present 5B Newborn Krt10
TS27: hyponychium Present 5B Newborn Krt10 Minor focal areas of specific nail differentiation were marked by the down-regulation of Krt10.
Specimen S2C wild type: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: eponychium Present S2C Krt10 wild type
Specimen S2C HoxC-/-: postnatal newborn; Hoxctm1Nogu/Hoxctm1Nogu (more )
Structure Level Pattern Image Note
TS27: eponychium Present S2C Krt10 HoxC-/-
TS27: hyponychium Present S2C Krt10 HoxC-/- Expression persisted in the digit tip epithelium.
Specimen S3 wild type: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: eponychium Present Regionally restricted S3_wild type Krt10 Expression was detected in the suprabasal layer.
Specimen S3 Hoxc13GFP/GFP: postnatal newborn; Hoxc13tm3.1Mrc/Hoxc13tm3.1Mrc (more )
Structure Level Pattern Image Note
TS27: eponychium Present Regionally restricted S3_Hoxc13GFP/GFP Krt10 Expression was detected in the suprabasal layer.
TS27: hyponychium Present Regionally restricted S3_Hoxc13GFP/GFP Krt10 Expression persisted in the suprabasal layers of the nail matrix.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory