Hoxc^em1Ddu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxc^em1Ddu
• Name: homeobox C cluster; endonuclease-mediated mutation 1, Denis Duboule
• MGI ID: MGI:7334777
• Synonyms: HoxC^del(EC1)
• Gene: Hoxc Location: unknown Genetic Position: Chr15, cytoband F1-F3

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR-targeting technology, the EC1 (Enhancer of HoxC cluster 1) located 165 kb upstream of the HoxC cluster was deleted. (J:297683)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc Mutation: 1 strain or line available

References

• Original: J:297683 Fernandez-Guerrero M, et al., Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30509-30519
• All: 1 reference(s)