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Gene Expression Data
Assay Details
Assay
Reference: J:284490 Varum S, et al., Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7332919
Gene symbol: Dct
Gene name: dopachrome tautomerase
Antibody: anti-TRP2
Detection system: Secondary antibody
Assay notes: Fixation was with 4% Roti-Histofix.
Results
Specimen 1L Control: embryonic day 13.5; Yy1tm2Yshi/Yy1+ (more )
Note: Control could be Yy1fl/+; Yy1fl/fl or Yy1fl/+;Wnt1-Cre.
Structure Cell Type Level Pattern Image Note
TS21: skin melanocyte Present 1L Control
Specimen 1L Yy1 cko: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Yy1tm2Yshi/Yy1tm2Yshi (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS21: skin melanocyte Trace 1L Yy1 cko Marked reduction in melanocyte numbers.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory