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Gene Expression Data
Assay Details
Assay
Reference: J:326355 Bademci G, et al., Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204084119
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7329771
Gene symbol: Gria2
Gene name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Antibody: anti-GluA2 (MAB397)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5A P14 12kHz +/+: postnatal day 14 (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P14 12kHz +/+ Expression marks postsynaptic densities.
Specimen 5A P14 12kHz +/tm1b: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2+ (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P14 12kHz +/tm1b Synapses appeared normal in numbers.
Specimen 5A P14 12kHz tm1b/tm1b: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P14 12kHz tm1b/tm1b Synapses appeared normal in numbers.
Specimen 5A P14 24kHz +/+: postnatal day 14 (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P14 24kHz +/+ Expression marks postsynaptic densities.
Specimen 5A P14 24kHz +/tm1b: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2+ (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P14 24kHz +/tm1b Synapses appeared normal in numbers.
Specimen 5A P14 24kHz tm1b/tm1b: postnatal day 14; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P14 24kHz tm1b/tm1b Synapses appeared normal in numbers.
Specimen 5A P30-P32 12kHz +/+: postnatal day 30-32 (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P30-P32 12kHz +/+ Expression marks postsynaptic densities.
Specimen 5A P30-P32 12kHz +/tm1b: postnatal day 30-32; Minar2tm1b(KOMP)Wtsi/Minar2+ (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P30-P32 12kHz +/tm1b Synapses appeared normal in numbers.
Specimen 5A P30-P32 12kHz tm1b/tm1b: postnatal day 30-32; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Weak Regionally restricted 5A P30-P32 12kHz tm1b/tm1b Authors report significantly fewer colocalized synapses compared to wild type and heterozygotes.
Specimen 5A P30-P32 24kHz +/+: postnatal day 30-32 (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P30-P32 24kHz +/+ Expression marks postsynaptic densities.
Specimen 5A P30-P32 24kHz +/tm1b: postnatal day 30-32; Minar2tm1b(KOMP)Wtsi/Minar2+ (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 5A P30-P32 24kHz +/tm1b Synapses appeared normal in numbers.
Specimen 5A P30-P32 24kHz tm1b/tm1b: postnatal day 30-32; Minar2tm1b(KOMP)Wtsi/Minar2tm1b(KOMP)Wtsi (more )
Note: Double labeled: green - GluR2 (Gria2); magenta - Ctbp2 (assay MGI:7329770).
Structure Level Pattern Image Note
TS28: cochlea Weak Regionally restricted 5A P30-P32 24kHz tm1b/tm1b Authors report significantly fewer colocalized synapses compared to wild type and heterozygotes.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory