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Gene Expression Data
Assay Details
Assay
Reference: J:320745 Ferguson CJ, et al., APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Mol Cell. 2022 Jan 6;82(1):90-105.e13
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7328851
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Results
Specimen 5M ctrl: postnatal day 11; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum external granule cell layer neural progenitor cell Present 5M ctrl Expression restricted to proliferating granule cell precursors
TS28: cerebellum internal granule cell layer Absent 5M ctrl

Specimen 5M Anapc7-/-: postnatal day 11; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum external granule cell layer neural progenitor cell Present 5M Anapc7-/- Expression in proliferating granule cell precursors.
TS28: cerebellum internal granule cell layer cerebellar granule cell Present Regionally restricted 5M Anapc7-/- Ectopic expression in mature cerebellar granule cells.

Specimen 7A ctrl: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS24: cerebral cortex Ambiguous 7A ctrl

Specimen 7A Anapc7-/-: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS24: cerebral cortex Present Regionally restricted 7A Anapc7-/- Expression outside of progenitor zones.

Specimen 7B ctrl: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS24: cortical plate Ambiguous 7B ctril Ki-67 , 7B ctrl merge

Specimen 7B Anapc7-/-: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS24: cortical plate Present Regionally restricted 7B Anapc7-/- merge , 7B Anapc7-/- Ki-67 Expression outside of progenitor zones.

Specimen S7A ctrl: postnatal day 11; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum external granule cell layer neural progenitor cell Present Regionally restricted S7A ctrl Ki-67 Expression restricted to proliferating granule cell precursors in outer EGL.

Specimen S7A Anapc7-/-: postnatal day 11; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present Regionally restricted S7A Anapc7-/- Ki-67 Expression outside of progenitor zones.

Specimen S7B ctrl: embryonic day 18.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS26: neocortex Present S7B ctril (right)

Specimen S7B Anapc7-/-: embryonic day 18.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS26: neocortex Present Regionally restricted S7B Anapc7-/- (right) Expression outside of progenitor zones.

Specimen S7C ctrl: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS24: telencephalon Present S7C ctrl

Specimen S7C Anapc7-/-: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS24: telencephalon Present Regionally restricted S7C Anapc7-/- Expression outside of progenitor zones.

Specimen S7D ctrl: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS24: diencephalon Present S7D ctrl (upper) , S7D ctrl (lower)

Specimen S7D Anapc7-/-: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS24: diencephalon Present Regionally restricted S7D Anapc7-/- (lower) , S7D Anapc7-/- (upper) Expression outside of progenitor zones.

Specimen S7E ctrl: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS24: brainstem Present S7E ctrl (lower) , S7E ctrl (upper)

Specimen S7E Anapc7-/-: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS24: brainstem Present Regionally restricted S7E Anapc7-/- (upper) , S7E Anapc7-/- (lower) Expression outside of progenitor zones.

Specimen S7F ctrl: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7+ (more )
Structure Level Pattern Image Note
TS24: hindbrain Present S7F ctrl

Specimen S7F Anapc7-/-: embryonic day 16.0; Anapc7tm1.1Azbi/Anapc7tm1.1Azbi (more )
Structure Level Pattern Image Note
TS24: hindbrain Present Regionally restricted S7F Anapc7-/- Expression outside of progenitor zones.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory