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Gene Expression Data
Assay Details
Assay
Reference: J:320689 Xu J, et al., Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation. Front Cell Dev Biol. 2022;10:815249
Assay type: RNA in situ
MGI Accession ID: MGI:7328524
Gene symbol: Wnt4
Gene name: wingless-type MMTV integration site family, member 4
Probe: Wnt4 probe15
Probe preparation: Antisense RNA
Results
Specimen 2M: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: cap mesenchyme Present 2M Expressed on the ventral side of the branching ureteric bud.
Specimen 2N: embryonic day 11.5; Eya1tm4(Six1)Px/Eya1+ (more )
Structure Level Pattern Image Note
TS19: cap mesenchyme Present 2N Expressed on the ventral side of the branching ureteric bud.
Specimen 2O: embryonic day 11.5; Eya1tm4(Six1)Px/Eya1+, Six2tm1Gco/Six2tm1Gco (more )
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present Regionally restricted 2O No global activation of expression in the entire metanephric mesenchyme, and higher levels of expression was detected on the ventral side of the branching ureteric bud.
Specimen 2P: embryonic day 11.5; Six2tm1Gco/Six2tm1Gco (more )
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present Widespread 2P Relatively uniform expression throughout the entire metanephric mesenchyme. The first branching T-shaped ureteric bud appeared as a single tube, and the ureteric bud tips were not induced to undergo second branching.
Specimen 2Q: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: renal vesicle Present 2Q
Specimen 2R: embryonic day 12.5; Eya1tm4(Six1)Px/Eya1+ (more )
Structure Level Pattern Image Note
TS20: renal vesicle Present 2R
Specimen 2S: embryonic day 12.5; Eya1tm4(Six1)Px/Eya1+, Six2tm1Gco/Six2tm1Gco (more )
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present 2S The pattern of expression appeared abnormal. The second branching was either incomplete or abnormal.
Specimen 2T: embryonic day 12.5; Six2tm1Gco/Six2tm1Gco (more )
Structure Level Pattern Image Note
TS20: mesenchyme of metanephros Present 2T Relatively uniform expression throughout the entire metanephric mesenchyme. The first branching T-shaped ureteric bud appeared as a single tube, and the ureteric bud tips were not induced to undergo second branching.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory