About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:308695 Talley MJ, et al., Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7281496
Gene symbol: Lztr1
Gene name: leucine-zipper-like transcriptional regulator, 1
Reporter: lacZ
Antibody: anti-B-galactosidase (Biogenesis, 4600-1409)
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 1J: postnatal month 1; Lztr1tm1b(EUCOMM)Wtsi/Lztr1+ (more )
Structure Level Pattern Image Note
TS28: corpus callosum Present 1J
Specimen 2K: postnatal day 21; Lztr1tm1b(EUCOMM)Wtsi/Lztr1+ (more )
Note: Double labeled: green - Lztr1 reporter; red - Olig2 (assay MGI:7281526).
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum oligodendrocyte Present Regionally restricted 2K Expression of Olig2 overlapped with beta-gal staining for Lztr1. However, there were many cells stained only with Olig2.
Specimen 2L: postnatal day 21; Lztr1tm1b(EUCOMM)Wtsi/Lztr1+ (more )
Note: Double labeled: green - Lztr1 reporter; red - Apc (assay MGI:7281527).
Structure Cell Type Level Pattern Image Note
TS28: corpus callosum oligodendrocyte Present Regionally restricted 2L A nearly complete overlap of immunostaining with the CC1 antibody was noted with beta-gal staining for Lztr1.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory