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Gene Expression Data
Assay Details
Assay
Reference: J:311933 Kong JH, et al., Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development. 2021 Oct 1;148(19):dev199867
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7279106
Gene symbol: Gli1
Gene name: GLI-Kruppel family member GLI1
Reporter: lacZ
Direct Detection
Results
Specimen 2B e8.5 Control (left): embryonic day 8.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmo+ (more )
Structure Level Pattern Image Note
TS13: neural tube Present 2B e8.5 Control (left)
TS13: secondary heart field Present 2B e8.5 Control (left)
TS13: somite Present 2B e8.5 Control (left)

Specimen 2B e8.5 Control (right): embryonic day 8.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmo+ (more )
Structure Level Pattern Image Note
TS13: neural tube Present 2B e8.5 Control (right)
TS13: secondary heart field Present 2B e8.5 Control (right)
TS13: somite Present 2B e8.5 Control (right)

Specimen 2B e8.5 Mosmo-/- (left): embryonic day 8.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS13: neural tube Strong 2B e8.5 Mosmo-/- (left) Expression elevated compared with control embryos.
TS13: secondary heart field Strong 2B e8.5 Mosmo-/- (left) Expression elevated compared with control embryos.
TS13: somite Strong 2B e8.5 Mosmo-/- (left) Expression elevated compared with control embryos.

Specimen 2B e8.5 Mosmo-/- (right): embryonic day 8.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS13: neural tube Strong 2B e8.5 Mosmo-/- (right) Expression elevated compared with control embryos.
TS13: secondary heart field Strong 2B e8.5 Mosmo-/- (right) Expression elevated compared with control embryos.
TS13: somite Strong 2B e8.5 Mosmo-/- (right) Expression elevated compared with control embryos.

Specimen S3B Control: embryonic day 9.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmo+ (more )
Structure Level Pattern Image Note
TS15: neural tube Present S3B Control
TS15: secondary heart field Present S3B Control
TS15: somite Present S3B Control

Specimen S3B Mosmo-/-: embryonic day 9.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS15: neural tube Strong S3B Mosmo-/- Expression elevated compared with control embryos.
TS15: secondary heart field Strong S3B Mosmo-/- Expression elevated compared with control embryos.
TS15: somite Strong S3B Mosmo-/- Expression elevated compared with control embryos.

Specimen 2B e11.5 Control (embryo): embryonic day 11.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmo+ (more )
Structure Level Pattern Image Note
TS19: diencephalon Present 2B e11.5 Control (embryo)
TS19: fronto-nasal process Present 2B e11.5 Control (embryo)
TS19: future spinal cord Present 2B e11.5 Control (embryo)
TS19: limb Present 2B e11.5 Control (embryo)
TS19: lung Present 2B e11.5 Control (embryo)
TS19: pharynx epithelium Present 2B e11.5 Control (embryo)
TS19: telencephalon Present 2B e11.5 Control (embryo)

Specimen 2B e11.5 Control Outflow tract: embryonic day 11.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmo+ (more )
Structure Level Pattern Image Note
TS19: outflow tract Present 2B e11.5 Control Outflow tract

Specimen 2B e11.5 Control Hindlimb: embryonic day 11.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmo+ (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Present 2B e11.5 Control Hindlimb

Specimen 2B e11.5 Mosmo-/- (embryo): embryonic day 11.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS19: diencephalon Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.
TS19: fronto-nasal process Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.
TS19: future spinal cord Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.
TS19: limb Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.
TS19: lung Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.
TS19: pharynx epithelium Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.
TS19: telencephalon Strong 2B e11.5 Mosmo-/- (embryo) Expression elevated compared with control embryos.

Specimen 2B e11.5 Mosmo-/- Outflow tract: embryonic day 11.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Strong 2B e11.5 Mosmo-/- Outflow tract Expression elevated compared with control embryos.

Specimen 2B e11.5 Mosmo-/- Hindlimb: embryonic day 11.5; Gli1tm2Alj/Gli1+, Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Strong Regionally restricted 2B e11.5 Mosmo-/- Hindlimb Elevated expression in anterior hindlimb.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory