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Gene Expression Data
Assay Details
Assay
Reference: J:324232 Oury J, et al., Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia. Nature. 2021 Jul;595(7867):404-408
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7278764
Gene symbol: Crkl
Gene name: Crk like proto-oncogene, adaptor protein
Antibody: CRK-L antibody (sc-365092)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2a Wild type: embryonic day 18.5 (more )
Note: Double labeled: green - Crkl; red - AChR.
Structure Level Pattern Image Note
TS26: limb muscle Present Regionally restricted 2a Wild type CRK-L , 2a Wild type Merge Expression in synapse.
Specimen 2a Dok7 CM/CM: embryonic day 18.5; Dok7em1Sjb/Dok7em1Sjb (more )
Note: Double labeled: green - Crkl; red - AChR.
Structure Level Pattern Image Note
TS26: limb muscle Weak Regionally restricted 2a Dok7 CM/CM CRK-L , 2a Dok7 CM/CM Merge Authors report expression in synapse substantially diminished compared with wild type.
Specimen 2a Dok7 2YF/2YF: embryonic day 18.5; Dok7em2Sjb/Dok7em2Sjb (more )
Note: Double labeled: green - Crkl; red - AChR.
Structure Level Pattern Image Note
TS26: limb muscle Present Regionally restricted 2a Dok7 2YF/2YF CRK-L , 2a Dok7 2YF/2YF Merge Expression in synapsed only modestly reduced compared with wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory