Dok7^em1Sjb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dok7^em1Sjb
• Name: docking protein 7; endonuclease-mediated mutation 1, Steven J Burden
• MGI ID: MGI:7278695
• Synonyms: Dok7^CM
• Gene: Dok7 Location: Chr5:35214110-35245183 bp, + strand Genetic Position: Chr5, 18.0 cM
• Alliance: Dok7^em1Sjb page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Duplication
• CRISPR-targeting inserted the TGCC duplication. (J:324232)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok7 Mutation: 30 strains or lines available

References

• Original: J:324232 Oury J, et al., Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia. Nature. 2021 Jul;595(7867):404-408
• All: 1 reference(s)