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Gene Expression Data
Assay Details
Assay
Reference: J:278471 Nakanishi H, et al., Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. Sci Rep. 2018 Aug 14;8(1):12125
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7266314
Gene symbol: Slc26a5
Gene name: solute carrier family 26, member 5
Antibody: anti-prestin (N-20; sc-22692)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 7B Tmc1 delta/delta Apical: postnatal day 16; Tmc1tm1.1Ajg/Tmc1tm1.1Ajg (more )
Note: Double labeled: green - prestin (Slc26a5); red - Myo7a (assay MGI:7266315).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear outer hair cell Present Regionally restricted 7B Tmc1 delta/delta Apical Expression along perimeter of outer hair cells .
Specimen 7B Tmc1 delta/delta Middle: postnatal day 16; Tmc1tm1.1Ajg/Tmc1tm1.1Ajg (more )
Note: Double labeled: green - prestin (Slc26a5); red - Myo7a (assay MGI:7266315).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear outer hair cell Present Regionally restricted 7B Tmc1 delta/delta Middle Expression along perimeter of outer hair cells. Outer hair cells were degenerating.
Specimen 7B Tmc1 delta/delta Basal: postnatal day 16; Tmc1tm1.1Ajg/Tmc1tm1.1Ajg (more )
Note: Double labeled: green - prestin (Slc26a5); red - Myo7a (assay MGI:7266315).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear outer hair cell Present Regionally restricted 7B Tmc1 delta/delta Basal Expression along perimeter of outer hair cells. Outer hair cells were degenerating.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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