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Gene Expression Data
Assay Details
Assay
Reference: J:311536 Kim BJ, et al., RERE deficiency causes retinal and optic nerve atrophy through degeneration of retinal cells. Dev Dyn. 2021 Oct;250(10):1398-1409
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7262882
Gene symbol: Rere
Gene name: arginine glutamic acid dipeptide (RE) repeats
Antibody: anti-RERE (H-113; sc-98415)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Alexa Fluor 568
Results
Specimen 1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: neural retina Present Regionally restricted 1A' , 1A Expression was primarily detected in the ciliary margin of the neural retina. A few immunopositive cells were seen in the bottom of the ganglion cell layer. Expressing cells were not detected in the neuroblast layer.
TS21: lens epithelium Present 1A

Specimen 1B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lens epithelium Present 1B' , 1B
TS23: retina layer Present Regionally restricted 1B , 1B" Broad expression was detected in the ganglion cell layer. Expression in the ciliary margin of the neural retina disappeared at E15.5. Expressing cells were not detected in the neuroblast layer.

Specimen 1C: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: ciliary body Present 1C' , 1C
TS25: retina layer Present Regionally restricted 1C Expression was detected in the ganglion cell layer. A few immunopositive cells were seen in the junction between the neuroblast layer and inner plexiform layer.

Specimen 1D: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 1D
TS28: retina inner nuclear layer Present 1D
TS28: retina outer nuclear layer Present 1D

Specimen 1E: embryonic day 17.5 (more )
Note: Double labeled: red - Rere; green - Pou4f2 (assay MGI:7262890).
Structure Cell Type Level Pattern Image Note
TS25: retina layer retinal ganglion cell Present Regionally restricted 1E , 1G A subset of Pou4f2-positive retinal ganglion cells was also Rere-immunopositive.
TS25: retina layer Present Regionally restricted 1G , 1E A few Rere-positive cells were also found in the junction between the neuroblast layer and the inner plexiform layer, which were not labeled with Pou4f2.

Specimen 2B Rere+/+: embryonic day 17.5 (more )
Note: Double labeled: red - Rere; green - Pou4f2 (assay MGI:7262890).
Structure Level Pattern Image Note
TS25: neural retina Present 2B Rere +/+ , 2B Rere/Brn3b +/+

Specimen 2B Rereom/eyes3: embryonic day 17.5; Rereeyes3/Rereom (more )
Note: Double labeled: red - Rere; green - Pou4f2 (assay MGI:7262890).
Structure Level Pattern Image Note
TS25: neural retina Weak 2B Rere om/eyes3 , 2B Rere/Brn3b om/eyes3


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory