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Gene Expression Data
Assay Details
Assay
Reference: J:309510 Beccari L, et al., Dbx2 regulation in limbs suggests interTAD sharing of enhancers. Dev Dyn. 2021 Sep;250(9):1280-1299
Assay type: RNA in situ
MGI Accession ID: MGI:7260198
Gene symbol: Dbx2
Gene name: developing brain homeobox 2
Probe: Dbx2 cDNA
Probe preparation: Antisense RNA
Results
Specimen 1A E10: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: forelimb bud mesenchyme Weak Regionally restricted 1A E10 Expressed throughout the limb bud mesenchyme, with the exception of mesodermal cells underlying the distal-most limb ectoderm.
Specimen 1A E11: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forelimb bud mesenchyme Present Regionally restricted 1A E11 Expression was confined to a small and posterior moon-shaped cellular domain, and in the anterior portion of the autopod.
Specimen 1A E12: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb digit mesenchyme Present Widespread 1A E12
TS20: forelimb interdigital region mesenchyme Present Widespread 1A E12
Specimen 1A E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: forelimb digit mesenchyme Present 1A E13
TS21: hand joint Present 1A E13
Specimen 1A E14: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: hand joint Present 1A E14
Specimen 5D Wt: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: forelimb digit mesenchyme Present 5D left
TS21: hand joint Present 5D left
Specimen 5D DLE1-/-: embryonic day 13.0; Dbx2em2Ddu/Dbx2em2Ddu (more )
Structure Level Pattern Image Note
TS21: forelimb digit mesenchyme Present 5D right Reduced expression compared with the wild-type.
TS21: hand joint Present 5D right Reduced expression compared with the wild-type.
Specimen 6B Wt: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: forelimb digit mesenchyme Present 6B-1
TS20: forelimb interdigital region mesenchyme Present 6B-1
Specimen 6B a13-/-: embryonic day 12.0; Hoxa13tm2Ipc/Hoxa13tm2Ipc (more )
Structure Level Pattern Image Note
TS20: forelimb digit mesenchyme Weak 6B-2 Strongly decreased expression compared with the wild-type. Expressed in the distal portion of the central digits only.
TS20: forelimb interdigital region mesenchyme Weak 6B-2 Strongly decreased expression compared with the wild-type. Expressed in the distal portion of the central digits only.
Specimen 6B d13-/-: embryonic day 12.0; Hoxd13tm1Ddu/Hoxd13tm1Ddu (more )
Structure Level Pattern Image Note
TS20: forelimb digit mesenchyme Present 6B-3 Only a weak reduction in expression compared with the wild-type, with the exception of the posterior-most portion of the autopod, where expression was severely reduced.
TS20: forelimb interdigital region mesenchyme Present 6B-3 Only a weak reduction in expression compared with the wild-type, with the exception of the posterior-most portion of the autopod, where expression was severely reduced.
Specimen 6B d13+/-a13-/-: embryonic day 12.0; Hoxa13tm2Ipc/Hoxa13tm2Ipc, Hoxd13tm1Ddu/Hoxd13+ (more )
Structure Level Pattern Image Note
TS20: forelimb digit mesenchyme Absent 6B-4
TS20: forelimb interdigital region mesenchyme Absent 6B-4
Specimen 6B d13-/-a13+/-: embryonic day 12.0; Hoxa13tm2Ipc/Hoxa13+, Hoxd13tm1Ddu/Hoxd13tm1Ddu (more )
Structure Level Pattern Image Note
TS20: forelimb digit mesenchyme Absent 6B-5
TS20: forelimb interdigital region mesenchyme Absent 6B-5
Specimen 6B d13-/-a13-/-: embryonic day 12.0; Hoxa13tm2Ipc/Hoxa13tm2Ipc, Hoxd13tm1Ddu/Hoxd13tm1Ddu (more )
Structure Level Pattern Image Note
TS20: hand mesenchyme Trace 6B-6 Expression was almost completely abrogated. A faint and spatially ill-defined signal was seen.
Specimen 8C E11: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: central nervous system Present 8C E11 Dbx2
TS18: limb bud Present 8C E11 Dbx2
Specimen 8C E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: forelimb digit mesenchyme Present 8C E13 Dbx2
TS21: hand joint Present 8C E13 Dbx2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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