Dbx2^em2Ddu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dbx2^em2Ddu
• Name: developing brain homeobox 2; endonuclease-mediated mutation 2, Denis Duboule
• MGI ID: MGI:7258340
• Synonyms: DLE^-
• Gene: Dbx2 Location: Chr15:95521444-95552838 bp, - strand Genetic Position: Chr15, 50.47 cM
• Alliance: Dbx2^em2Ddu page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of the third exon and enhancer deleted 1015 bp deletion (chr15:95600674-95 602 176, mm10) encompassing the first distal limb enhancer (DLE1) sequence. (J:309510)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dbx2 Mutation: 20 strains or lines available

References

• Original: J:309510 Beccari L, et al., Dbx2 regulation in limbs suggests interTAD sharing of enhancers. Dev Dyn. 2021 Sep;250(9):1280-1299
• All: 1 reference(s)