About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:314664 Harada Y, et al., Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module. Nat Commun. 2021 Nov 12;12(1):6562
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6860525
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2 (3728)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 5c Hey1+/+: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lateral ganglionic eminence Present Regionally restricted 5c Hey1+/+ (lower) , 5c Hey1+/+ (upper) Expression in undifferenciated neural stem-progenitor cells (NPCs).
Specimen 5c Hey1-/-: embryonic day 16.5; Hey1tm1Kkb/Hey1tm1Kkb (more )
Structure Level Pattern Image Note
TS24: lateral ganglionic eminence Weak Regionally restricted 5c Hey1-/- (lower) , 5c Hey1-/- (upper) Number of expressing cells in dorsal one-fourth of lateral ganglionic eminence (dLGE) at level of rostral one-third of rostral-caudal axis was significantly lower for Hey1 knockout than for control.
Specimen 5e Hey1+/+: postnatal day 21 (more )
Note: Triple labeled: red - Sox2; green - Gfap (assay MGI:6860526); white - S100b (assay MGI:6860527).
Structure Level Pattern Image Note
TS28: brain subventricular zone Present Regionally restricted 5e Hey1+/+ (upper) , 5e Hey1+/+ (lower) Expression in neural stem cells (NSCs).
Specimen 5e Hey1-/-: postnatal day 21; Hey1tm1Kkb/Hey1tm1Kkb (more )
Note: Triple labeled: red - Sox2; green - Gfap (assay MGI:6860526); white - S100b (assay MGI:6860527).
Structure Level Pattern Image Note
TS28: brain subventricular zone Weak Regionally restricted 5e Hey1-/- (upper) , 5e Hey1-/- (lower) Expression significantly reduced in subventricular zone (SVZ) of knockout compared to control.
Specimen 7d Hey1+/+: embryonic day 14.5 (more )
Note: Double labeled: red - Sox2; green - Ascl1 (assay MGI:6860530).
Structure Level Pattern Image Note
TS22: lateral ganglionic eminence Present 7d Hey1+/+
Specimen 7d Hey1-/-: embryonic day 14.5; Hey1tm1Kkb/Hey1tm1Kkb (more )
Note: Double labeled: red - Sox2; green - Ascl1 (assay MGI:6860530).
Structure Level Pattern Image Note
TS22: lateral ganglionic eminence Present 7d Hey1-/-
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory