Sox10 Northern blot Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:47640 Herbarth B, et al., Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5161-5
Assay type:	Northern blot
MGI Accession ID:	MGI:6842950
Gene symbol:	Sox10
Gene name:	SRY (sex determining region Y)-box 10

Probe:	Sox10 probe29
Probe preparation:	Double stranded labelled with P32 DNA

Results

	Sample Information		Bands	Other Sample Information
Lane	Age	Structure	Size Not Specified	Amount	Genetic Background	Mutant Allele(s)	Sex
whole brain Dom/+	P newborn	TS27: brain	Present	10 µg; total RNA	involves: C3H/HeOuJ * C57BL/6JLe	Sox10^Dom/Sox10⁺	Not Specified
whole brain Dom/Dom	P newborn	TS27: brain	Present (a)	10 µg; total RNA	involves: C3H/HeOuJ * C57BL/6JLe	Sox10^Dom/Sox10^Dom	Not Specified
intestine +/+	P newborn	TS27: intestine	Present	10 µg; total RNA	involves: C57BL/6J		Not Specified
intestine Dom/+	P newborn	TS27: intestine	Weak (b)	10 µg; total RNA	involves: C3H/HeOuJ * C57BL/6JLe	Sox10^Dom/Sox10⁺	Not Specified
intestine Dom/Dom	P newborn	TS27: intestine	Absent (c)	10 µg; total RNA	involves: C3H/HeOuJ * C57BL/6JLe	Sox10^Dom/Sox10^Dom	Not Specified

Notes:
(a) Expression level was not reduced in brain of homozygous murants compared to heterozygous or wildtype littermates.
(b) Expression reduced in intestnie of heterozygotes.
(c) Expression below the level of detection.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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