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Gene Expression Data
Assay Details
Assay
Reference: J:308708 Martinez ME, et al., The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain. Front Neurosci. 2021;15:703730
Assay type: RNA in situ
MGI Accession ID: MGI:6842529
Gene symbol: Klf9
Gene name: Kruppel-like transcription factor 9
Probe: Mm-Klf9 (488371)
Probe preparation: Antisense
Assay notes: RNAscope assay.
Results
Specimen 2B +/+: embryonic day 18.5 (more )
Note: coronal section
Structure Level Pattern Image Note
TS26: brain Present 2B +/+
TS26: neocortex Strong Non-Uniform 2B +/+ There is strong expression in the neocortex, except for the most external layer.
TS26: frontal cortex Present 2D +/+ , 2B +/+ , 2C +/+ Expression is seen in the motor cortex.
TS26: parietal cortex Present 2D +/+ , 2B +/+ Expression is seen in the sensory cortex.
TS26: cortical plate Present 2E +/+ , 2B +/+ , 2F +/+ Expression is seen in both external and deeper cortical layers.
TS26: telencephalon subventricular zone Present 2B +/+ , 2G +/+ Expression is seen in the periventricular zone of the lateral ventricle.

Specimen 2B -/-: embryonic day 18.5; Dio3tm1Stg/Dio3tm1Stg (more )
Structure Level Pattern Image Note
TS26: brain Present 2B -/- Expression levels are increased in most cortical and striatal areas in the mutant.
TS26: neocortex Strong Non-Uniform 2B -/- There is strong expression in the neocortex, except for the most external layer; there are increases in multiple areas in the mutant.
TS26: frontal cortex Present 2B -/- , 2D -/- , 2C -/- Expression is seen in the motor cortex; it is increased in the mutant.
TS26: parietal cortex Present 2D -/- , 2B -/- Expression is seen in the sensory cortex; it is increased in the mutant.
TS26: cortical plate Present 2F -/- , 2B -/- , 2E -/- Expression is seen in both external and deeper cortical layers; it is increased in the mutant.
TS26: telencephalon subventricular zone Present 2B -/- , 2G -/- Expression is seen in the periventricular zone of the lateral ventricle; levels are similar in mutant and wild type.

Specimen S1A +/+: embryonic day 18.5 (more )
Note: coronal section close to bregma
Structure Level Pattern Image Note
TS26: brain Present S1A +/+
TS26: telencephalon septum Present S1B +/+ , S1A +/+ Expression is seen in the triangular septal nucleus.
TS26: corpus striatum Present S1C +/+ , S1A +/+ Expression is seen in the striatum.
TS26: telencephalon subventricular zone Present S1D +/+ , S1A +/+ Expression is seen in the periventricular zone of the lateral ventricle.
TS26: diencephalon subventricular zone Present S1A +/+ , S1F +/+ , S1E +/+ Expression is seen in the periventricular zone of the third ventricle.

Specimen S1A -/-: embryonic day 18.5; Dio3tm1Stg/Dio3tm1Stg (more )
Structure Level Pattern Image Note
TS26: brain Present S1A -/- Expression levels are increased in most cortical and striatal areas in the mutant.
TS26: telencephalon septum Present S1A -/- , S1B -/- Expression is seen in the triangular septal nucleus; it is increased in the mutant.
TS26: corpus striatum Present S1A -/- , S1C -/- Expression is seen in the striatum; it is increased in the mutant.
TS26: telencephalon subventricular zone Present S1A -/- , S1D -/- Expression is seen in the periventricular zone of the lateral ventricle; levels are similar in mutant and wild type.
TS26: diencephalon subventricular zone Present S1F -/- , S1A -/- , S1E -/- Expression is seen in the periventricular zone of the third ventricle; levels are modestly increased in the mutant relative to wild type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory