Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cckbrtm1.1(cre)Mgmj
Name:	cholecystokinin B receptor; targeted mutation 1.1, Martin G Myers, Jr
MGI ID:	MGI:6834787
Synonyms:	CckbrCre
Gene:	Cckbr  Location: Chr7:105075201-105085546 bp, + strand  Genetic Position: Chr7, 55.86 cM
Alliance:	Cckbrtm1.1(cre)Mgmj page

Germline Transmission:	Earliest citation of germline transmission: J:316161
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Cckbrtm1.1(cre)Mgmj expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cckbr (MGI:99479)   Mutation details: Using homologous recombination in ES cells, a T2A sequence and a CreER(T2) fusion gene were inserted immediately downstream of the cholecystokinin B receptor locus (Cckbr) on chromosome 7. The targeting vector contained, from 5' to 3', a viral 2A oligopeptide sequence (T2A; mediates ribosomal skipping), a Cre recombinase gene, a bovine growth hormone polyA sequence, an frt site, a PGK-neo-polyA cassette, and an frt site. Founder mice were bred with Flpo-expressing mice to delete the PGK-neo-polyA cassette. (J:316161)

Activity:	Tissue activity of this recombinase allele
Driver:	Cckbr (mouse) Summary of all recombinase alleles driven by Cckbr. Comparative matrix view of recombinase activities Alliance mouse Cckbr gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cckbr Mutation:	23 strains or lines available

Original:	J:316161 Flak JN, et al., Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020 Jun 1;130(6):2943-2952
All:	1 reference(s)