Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tp(X)1SoffTg(Myh11-icre/ERT2)1Soff
Name:	transposition, Chr X, Offermanns 1; transgene insertion 1, Stefan Offermanns
MGI ID:	MGI:6830915
Gene:	Tp(X)1Soff  Location: unknown  Genetic Position: ChrX, Syntenic

Strain of Origin:

FVB/N

Allele Type:    Spontaneous (Recombinase) Mutation:    Translocation   Tp(X)1SoffTg(Myh11-icre/ERT2)1Soff expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Myh11 (MGI:102643)   Mutation details: The mouse promoter from BAC clone 26630 was used to drive inducible icre expression in smooth muscle cells. An FRT-flanked beta-lactamase gene contained within the cre/ESR1 cassette was removed by flp mediated recombination. The transgene that originally integrated into Chr Y was found to to have translocated to Chr X in some female mice in the colony. The exact position is unknown. (J:248193)

Activity:	Tissue activity of this recombinase allele
Driver:	Myh11 (mouse) Summary of all recombinase alleles driven by Myh11. Comparative matrix view of recombinase activities Alliance mouse Myh11 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tp(X)1Soff Mutation:	1 strain or line available

Original:	J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8
All:	3 reference(s)