Cspg4 Immunohistochemistry Gene Expression Assay - GXD

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Gene Expression Data
Assay Details

Assay

Reference:	J:150211 Downes M, et al., Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet. 2009 Aug 1;18(15):2839-50
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6783425
Gene symbol:	Cspg4
Gene name:	chondroitin sulfate proteoglycan 4

Antibody:	anti-NG2
Detection system:	Secondary antibody

Results

Specimen 6B WT left: embryonic day 13.5 (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present	Regionally restricted	6B WT left	Expression is in pericytes of major vasculature.
TS21: great vessel of heart	Present	Regionally restricted	6B WT left	Expression is in pericytes of major vasculature.

Specimen 6B WT right: embryonic day 13.5 (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present	Regionally restricted	6B WT right	Expression is in pericytes in the subdermal microvasculature.

Specimen 6B Ra^Op/Ra^Op left: embryonic day 13.5; Sox18^Ra-Op/Sox18^Ra-Op (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present	Regionally restricted	6B Ra^Op/Ra^Op left	Expression is in pericytes of major vasculature is the same in this mutant compared to wild-type.

Specimen 6B Ra^Op/Ra^Op right: embryonic day 13.5; Sox18^Ra-Op/Sox18^Ra-Op (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present		6B Ra^Op/Ra^Op right	In this mutant significantly fewer microvessels (9.3%) were associated with positive pericytes compared to wild-type (17.8%).

Specimen S1 WT: embryonic day 13.5 (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present	Regionally restricted	S1_WT NG2 , S1_WT merge	Expression is in pericytes.

Specimen S1 Ra^Op/Ra^Op left: embryonic day 13.5; Sox18^Ra-Op/Sox18^Ra-Op (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present	Regionally restricted	S1_Ra^Op/Ra^Op NG2 left , S1_Ra^Op/Ra^Op Merge left	In this mutant significantly fewer microvessels (9.3%) were associated with positive pericytes compared to wild-type (17.8%).

Specimen S1 Ra^Op/Ra^Op right: embryonic day 13.5; Sox18^Ra-Op/Sox18^Ra-Op (more

)
Note: Double labeled: red - Cspg4; green - Pecam1 (assay MGI:6783426).

Structure	Level	Pattern	Image	Note
TS21: blood vessel	Present	Regionally restricted	S1_Ra^Op/Ra^Op NG2 right , S1_Ra^Op/Ra^Op Merge right	In this mutant significantly fewer microvessels (9.3%) were associated with positive pericytes compared to wild-type (17.8%).

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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