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Gene Expression Data
Assay Details
Assay
Reference: J:310161 Fujima S, et al., CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. J Neurosci. 2021 May 19;41(20):4524-4535
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6766411
Gene symbol: Cadps2
Gene name: Ca2+-dependent activator protein for secretion 2
Antibody: anti-a1803/CAPS2
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A: postnatal month 3-6 (more )
Note: Coronal section. Double labeled: red - Cadps2; green - Oxt (assay MGI:6766409).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present 1A CAPS2 , 1A Magnified , 1A Merged Expression is seen in neurons.
Specimen 1B: postnatal month 3-6 (more )
Note: Coronal section. Triple labeled: red - Cadps2; green - Oxt (assay MGI:6766409); blue - Avp (assay MGI:6766413).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present 1B Expression is seen in neurons.
Specimen 2A: postnatal month 3-6 (more )
Note: Coronal section. Double labeled: red - Cadps2; green - Oxt (assay MGI:6766409).
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Strong 2A CAPS2 , 2A Merge
TS28: neurohypophysis Moderate 2A CAPS2 , 2A Merge
Specimen 2B: postnatal month 3-6 (more )
Note: Triple labeled: red - Cadps2; green - Oxt (assay MGI:6766409); blue - Nos3 (assay MGI:6766414).
Structure Level Pattern Image Note
TS28: neurohypophysis Present Regionally restricted 2B left , 2B CAPS2 inset , 2B OXT/CAPS2 inset Expression is areas near blood vessels.
Specimen 2C WT: postnatal month 3-6 (more )
Note: Double labeled: red - Cadps2; green - Oxt (assay MGI:6766409).
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Strong 2C WT CAPS2 , 2C WT Merge
TS28: neurohypophysis Moderate 2C WT Merge , 2C WT CAPS2
Specimen 2C KO: postnatal month 3-6; Cadps2tm1Tfr/Cadps2tm1Tfr (more )
Note: Double labeled: red - Cadps2; green - Oxt (assay MGI:6766409).
Structure Level Pattern Image Note
TS28: pituitary gland Absent 2C KO CAPS2 , 2C KO Merge
Specimen 6B control: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak (more )
Note: Coronal section. Double labeled: red - Cadps2; green - Oxt (assay MGI:6766409).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present 6B control Merged , 6B control CAPS2 , 6B control Magnified
Specimen 6B cKO: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak, Oxttm1.1(icre)Ksak/Oxt+ (more )
Note: Conditional mutant. Coronal section. Double labeled: red - Cadps2; green - Oxt (assay MGI:6766409).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Absent 6B cKO Merged , 6B cKO CAPS2 , 6B cKO Magnified There is almost no detectable level of expression in the mutant.
Specimen 7A control: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Strong 7A control
TS28: neurohypophysis Moderate 7A control
Specimen 7A cKO: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak, Oxttm1.1(icre)Ksak/Oxt+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Strong 7A cKO Expression levels are similar to those seen in wild type.
TS28: neurohypophysis Absent 7A cKO
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory