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Gene Expression Data
Assay Details
Assay
Reference: J:310161 Fujima S, et al., CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior. J Neurosci. 2021 May 19;41(20):4524-4535
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6766409
Gene symbol: Oxt
Gene name: oxytocin
Antibody: Anti-Oxytocin Antibody, clone 4G11
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A: postnatal month 3-6 (more )
Note: Coronal section. Double labeled: green - Oxt; red - Cadps2 (assay MGI:6766411).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present Regionally restricted 1A OXT , 1A Magnified , 1A Merged Expression is seen in neurons.
Specimen 1B: postnatal month 3-6 (more )
Note: Coronal section. Triple labeled: green - Oxt; red - Cadps2 (assay MGI:6766411); blue - Avp (assay MGI:6766413).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present Regionally restricted 1B Expression is seen in neurons.
Specimen 2A: postnatal month 3-6 (more )
Note: Coronal section. Double labeled: green - Oxt; red - Cadps2 (assay MGI:6766411).
Structure Level Pattern Image Note
TS28: neurohypophysis Present 2A OXT , 2A Merge
Specimen 2B: postnatal month 3-6 (more )
Note: Triple labeled: green - Oxt; red - Cadps2 (assay MGI:6766411); blue - Nos3 (assay MGI:6766414).
Structure Level Pattern Image Note
TS28: neurohypophysis Present 2B left , 2B OXT/CAPS2 inset , 2B OXT inset
Specimen 2C WT: postnatal month 3-6 (more )
Note: Double labeled: green - Oxt; red - Cadps2 (assay MGI:6766411).
Structure Level Pattern Image Note
TS28: neurohypophysis Present 2C WT Merge , 2C WT OXT
Specimen 2C KO: postnatal month 3-6; Cadps2tm1Tfr/Cadps2tm1Tfr (more )
Note: Double labeled: green - Oxt; red - Cadps2 (assay MGI:6766411).
Structure Level Pattern Image Note
TS28: neurohypophysis Present 2C KO OXT , 2C KO Merge
Specimen 3C WT: postnatal month 3-6 (more )
Structure Level Pattern Image Note
TS28: neurohypophysis Present 3C WT , 3Ca WT
Specimen 3C KO: postnatal month 3-6; Cadps2tm1Tfr/Cadps2tm1Tfr (more )
Structure Level Pattern Image Note
TS28: neurohypophysis Present 3C Caps2 KO , 3Ca Caps2 KO The number of staining puncta is increased in the mutant.
Specimen 4B: postnatal month 3-6; Oxttm1.1(icre)Ksak/Oxt+ (more )
Note: Coronal section. Double labeled: green - Oxt protein; red - Oxt reporter (assay MGI:6764599).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present 4B Merge , 4B OXT Expression is seen in neurons.
Specimen 6B control: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak (more )
Note: Coronal section. Double labeled: green - Oxt; red - Cadps2 (assay MGI:6766411).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present 6B control Merged , 6B control Magnified , 6B control OXT
Specimen 6B cKO: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak, Oxttm1.1(icre)Ksak/Oxt+ (more )
Note: Conditional mutant. Coronal section. Double labeled: green - Oxt; red - Cadps2 (assay MGI:6766411).
Structure Level Pattern Image Note
TS28: paraventricular hypothalamic nucleus Present 6B cKO OXT , 6B cKO Merged , 6B cKO Magnified The number of staining cells is the same in the mutant as in wild type.
Specimen 7B control: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak (more )
Structure Level Pattern Image Note
TS28: neurohypophysis Present 7Ba control , 7B control
Specimen 7B cKO: postnatal month 3-6; Cadps2tm1.1Ksak/Cadps2tm1.1Ksak, Oxttm1.1(icre)Ksak/Oxt+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: neurohypophysis Present 7Bb cKO , 7B cKO The number of staining puncta is increased in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
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