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Igs2em9(Ctsk-icre)Gpt
Endonuclease-mediated Allele Detail
Summary
Symbol: Igs2em9(Ctsk-icre)Gpt
Name: intergenic site 2; endonuclease-mediated mutation 9, GemPharmatech Co., Ltd
MGI ID: MGI:6765437
Synonyms: CtskCre, H11em1Cin(Ctsk-iCre-polyA)
Gene: Igs2  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance: Igs2em9(Ctsk-icre)Gpt page
Mutation
origin
Strain of Origin:  C57BL/6JGpt
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Igs2em9(Ctsk-icre)Gpt expression driven by 1 gene
 
Mutation detailsCRISPR-targeting introduced the mouse promoter driving osteoclast-specific expression of the improved cre recombinase gene. (J:310893)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ctsk (mouse)
Summary of all recombinase alleles driven by Ctsk.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igs2 Mutation:  68 strains or lines available
References
Original:  J:310893 Xiao D, et al., PDK1 is important lipid kinase for RANKL-induced osteoclast formation and function via the regulation of the Akt-GSK3beta-NFATc1 signaling cascade. J Cell Biochem. 2020 Nov;121(11):4542-4557
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory