Tg(MMTV-CCND1*K112E)#Rgp
Transgene Detail
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| Symbol: |
Tg(MMTV-CCND1*K112E)#Rgp |
| Name: |
transgene insertion, Richard G Pestell |
| MGI ID: |
MGI:6758519 |
| Synonyms: |
MMTV-CCND1KE |
| Transgene: |
Tg(MMTV-CCND1*K112E)#Rgp Location: unknown
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| Alliance: |
Tg(MMTV-CCND1*K112E)#Rgp page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(MMTV-CCND1*K112E)#Rgp expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CCND1 (595) |
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human cDNA with a mutation disabling kinase activity |
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Mutation details: A mutated form of the human cyclin D1 cDNA, preceded by sequence for a N-terminal 2xFLAG tag and followed by SV40 poly(A) signal sequences, was placed downstream of the mouse mammary tumor virus promoter. The mutation is a G-to-A mutation that changes lysine codon 112 to a glutamic acid codon (p.K112E), eliminating or severely reducing the protein's phosphorylation (kinase) activity.
(J:309458)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:309458 Casimiro MC, et al., Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget. 2015 Apr 20;6(11):8525-38 |
| All: |
1 reference(s) |
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Analysis Tools
