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Gene Expression Data
Assay Details
Assay
Reference: J:203997 Krawchuk D, et al., FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst. Dev Biol. 2013 Dec 1;384(1):65-71
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6752540
Gene symbol: Sox17
Gene name: SRY (sex determining region Y)-box 17
Results
Specimen 1A: embryonic day 3.75 (more )
Note: Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS5: inner cell mass Present Regionally restricted 1A Expression in primitive endoderm progenitors.
Specimen 1B: embryonic day 3.75; Fgf4tm1.3Mrt/Fgf4+ (more )
Note: Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS5: inner cell mass Present Regionally restricted 1B No significant reduction in proportion of primitive endoderm progenitors compared with wild type embryos.
Specimen 1C: embryonic day 3.75; Fgf4tm1.3Mrt/Fgf4tm1.3Mrt (more )
Note: Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS5: inner cell mass Absent 1C
Specimen 1D: embryonic day 3.75; Fgf4tm1.2Mrt/Fgf4+, Tg(Zp3-cre)93Knw/0 (more )
Note: Conditional mutant. Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS5: inner cell mass Weak Regionally restricted 1D Authors report a reduction in proportion of primitive endoderm progenitors.
Specimen 1E: embryonic day 3.75; Fgf4tm1.2Mrt/Fgf4tm1.3Mrt, Tg(Zp3-cre)93Knw/0 (more )
Note: Conditional mutant. Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS5: inner cell mass Absent 1E
Specimen 4A: embryonic day 4.5 (more )
Note: Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS6: primitive endoderm Present 4A
Specimen 4B: embryonic day 4.5; Fgf4tm1.3Mrt/Fgf4+ (more )
Note: Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS6: primitive endoderm Present 4B Embryos morphologically indistinguishable from wild type.
Specimen 4C: embryonic day 4.5; Fgf4tm1.2Mrt/Fgf4+, Tg(Zp3-cre)93Knw/0 (more )
Note: Conditional mutant. Triple labeled: green - Sox17; red - Nanog (assay MGI:6752539); blue - Cdx2 (assay MGI:6752541).
Structure Level Pattern Image Note
TS6: primitive endoderm Weak 4C Reduction in primitive endoderm cells compared with wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory