Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Aqp5tm1.1(cre/ERT2)Ptch
Name:	aquaporin 5; targeted mutation 1.1, Pao-Tien Chuang
MGI ID:	MGI:6741118
Synonyms:	Aqp5CreER
Gene:	Aqp5  Location: Chr15:99488909-99492710 bp, + strand  Genetic Position: Chr15, 56.13 cM
Alliance:	Aqp5tm1.1(cre/ERT2)Ptch page

Germline Transmission:	Earliest citation of germline transmission: J:290280
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Aqp5tm1.1(cre/ERT2)Ptch expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aqp5 (MGI:106215)   Mutation details: A cre/ER fusion construct followed by an FRT flanked PGK neo selection cassette was inserted to replace the ATG translational start codon. The selection cassette was subsequently removed by crossing properly targeted mice to mice expressing flp recombinase. (J:290280)

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp5 (mouse) Summary of all recombinase alleles driven by Aqp5. Alliance mouse Aqp5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp5 Mutation:	16 strains or lines available

Original:	J:290280 Zhang K, et al., A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. Elife. 2020 May 12;9:e53688
All:	1 reference(s)