Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Relb-cre)53Rie
Name:	transgene insertion 53, Marc Riemann
MGI ID:	MGI:6729308
Synonyms:	RelbCre-Kat, Relb-Cre-P2A-Katushka
Transgene:	Tg(Relb-cre)53Rie  Location: unknown
Alliance:	Tg(Relb-cre)53Rie page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Recombinase, Reporter) Mutation:    Insertion   Tg(Relb-cre)53Rie expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Relb (MGI:103289)   Mutation details: The transgene consists of a bacterial artificial chromosome (BAC) of 93 kb (bMQ-258 k08) containing the complete Relb locus with 45 kb of upstream region was modified by introducing the gene coding for a Cre recombinase and Katushka, both linked by a self-cleaving P2A peptide into the first exon of the Relb gene just downstream of the translation initiation codon. Katushka (TurboFP635) is a far-red mutant of the red fluorescent protein from sea anemone Entacmaea quadricolor. Four founder mice were obtained, which transmitted the transgene to the progeny. In one of these founder lines (#53) transgene expression reflected that of endogenous Relb which was used for further study. (J:270571, J:292655)

Activity:	Tissue activity of this recombinase allele
Driver:	Relb (mouse) Summary of all recombinase alleles driven by Relb. Comparative matrix view of recombinase activities Alliance mouse Relb gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:270571 Riemann M, et al., Central immune tolerance depends on crosstalk between the classical and alternative NF-kappaB pathways in medullary thymic epithelial cells. J Autoimmun. 2017 Jul;81:56-67
All:	3 reference(s)