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Gene Expression Data
Assay Details
Assay
Reference: J:177992 Nowell CS, et al., Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011 Nov;7(11):e1002348
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6725788
Gene symbol: Aire
Gene name: autoimmune regulator
Antibody: anti-AIRE
Results
Specimen 1H AIRE: postnatal week 6; Foxn1tm1.1Cbln/Foxn1+ (more )
Note: Double labeled: red - AIRE; green - pan-cytokeratin.
Structure Level Pattern Image Note
TS28: thymus medulla epithelium Ambiguous 1H AIRE/panK , 1H AIRE Expression in medullary thymic epithelial cells.
Specimen 3H AIRE: postnatal week 6; Foxn1tm1.1Cbln/Foxn1tm1.1Cbln (more )
Note: Double labeled: red - AIRE; green - pan-cytokeratin.
Structure Level Pattern Image Note
TS28: thymus medulla epithelium Ambiguous 3H AIRE/panK , 3H AIRE Signficantly fewer expressing cells compared to wild type.
Specimen 3I -4OHT AIRE: postnatal week 4; Foxn1tm1.1Cbln/Foxn1tm1Tbo, Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Specimens are from uninjected littermate controls. Double labeled: green - AIRE: red - pan-cytokeratin.
Structure Level Pattern Image Note
TS28: thymus medulla epithelium Ambiguous 3I -4OHT AIRE/panK
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory