Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Qrfptm2.1(icre)Stak
Name:	pyroglutamylated RFamide peptide; targeted mutation 2.1, Takeshi Sakurai
MGI ID:	MGI:6724026
Synonyms:	QrfpiCre
Gene:	Qrfp  Location: Chr2:31696180-31700592 bp, - strand  Genetic Position: Chr2, 21.89 cM
Alliance:	Qrfptm2.1(icre)Stak page

Germline Transmission:	Earliest citation of germline transmission: J:294111
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Qrfptm2.1(icre)Stak expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Qrfp (MGI:3630329)   Mutation details: A targeting vector was designed to replace the entire coding region of the prepro-Qrfp sequence in exon 2 of the Qrfp gene with iCre and a pgk-Neo cassette so that the endogenous Qrfp promoter drives the expression of iCre. The Pgk-Neo cassette was deleted by crossing the mice with FLP66 mice. It is a knock-in, knock-out allele. (J:294111)

Activity:	Tissue activity of this recombinase allele
Driver:	Qrfp (mouse) Summary of all recombinase alleles driven by Qrfp. Comparative matrix view of recombinase activities Alliance mouse Qrfp gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Qrfp Mutation:	11 strains or lines available

Original:	J:294111 Takahashi TM, et al., A discrete neuronal circuit induces a hibernation-like state in rodents. Nature. 2020 Jul;583(7814):109-114
All:	4 reference(s)