Gene Expression Data
Assay Details
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Assay
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Reference:
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J:244562
Giese APJ, et al., CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017 Jun 29;8(1):43
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6723924
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Gene symbol:
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Myo7a
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Gene name:
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myosin VIIA
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Results
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Specimen
S4a Apical:
(close  )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4a Medial:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4a Basal:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4b P0 Apical:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4b P0 Medial:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4b P0 Basal:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4b P16 Apical:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4b P16 Medial:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4b P16 Medial
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Outer hair cells start to degenerate in mid-basal part of cochlea by P16-18. Inner hair cells largely intact.
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Specimen
S4b P16 Basal:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4b P16 Basal
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Outer hair cells start to degenerate in mid-basal part of cochlea by P16-18. Inner hair cells largely intact.
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Specimen
S4b P27 Apical:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 27
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4b P27 Medial:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 27
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4b P27 Medial
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Outer hair cell degeneration exacerbated by P27. Some inner hair cells missing at P27.
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Specimen
S4b P27 Basal:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 27
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4b P27 Basal
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Outer hair cell degeneration exacerbated by P27. Some inner hair cells missing at P27.
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Specimen
S4c P0 tm1a/+:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4c P0 tm1a/tm1a:
(close )
Specimen
S4c P0 F91S/F91S:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1.1Zma/Cib2tm1.1Zma
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4c P16 tm1a/+:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4c P16 tm1a/tm1a:
(close )
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4c P16 tm1a/tm1a
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Outer hair cells start to degenerate in mid-basal part of cochlea by P16-18. Inner hair cells largely intact.
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Specimen
S4c P16 F91S/F91S:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1.1Zma/Cib2tm1.1Zma
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Age:
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postnatal day 16
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4c P16 F91S/F91S
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Outer hair cells start to degenerate in mid-basal part of cochlea by P16-18. Inner hair cells largely intact.
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Specimen
S4c P22 tm1a/+:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 22
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4c P22 tm1a/tm1a:
(close )
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4c P22 tm1a/tm1a
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Outer hair cells start to degenerate in mid-basal part of cochlea by P16-18. Inner hair cells largely intact.
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Specimen
S4c P18 F91S/F91S:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1.1Zma/Cib2tm1.1Zma
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Age:
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postnatal day 18
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
S4c P18 F91S/F91S
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Outer hair cells start to degenerate in mid-basal part of cochlea by P16-18. Inner hair cells largely intact.
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Specimen
S4c P27 tm1a/+:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 27
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S4c P27 tm1a/tm1a:
(close )
Specimen
S4c P24 F91S/F91S:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1.1Zma/Cib2tm1.1Zma
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Age:
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postnatal day 24
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Specimen
S6a MyoVIIa tm1a/+:
postnatal day 18; Cib2tm1a(EUCOMM)Wtsi/Cib2 +
(more  )
Note: Triple labeled: green - Myosin VIIa (Myo7a); cyan - alpha-acetylated tubulin; red - phalloidin.
Specimen
S6a MyoVIIa tm1a/+:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2+
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Age:
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postnatal day 18
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Note:
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Triple labeled: green - Myosin VIIa (Myo7a); cyan - alpha-acetylated tubulin; red - phalloidin.
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Specimen
S6a MyoVIIa tm1a/tm1a:
postnatal day 18; Cib2tm1a(EUCOMM)Wtsi/ Cib2tm1a(EUCOMM)Wtsi
(more )
Note: Triple labeled: green - Myosin VIIa (Myo7a); cyan - alpha-acetylated tubulin; red - phalloidin.
Specimen
S6a MyoVIIa tm1a/tm1a:
(close )
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Genetic Background:
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involves: C57BL/6N
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Mutant Allele(s):
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Cib2tm1a(EUCOMM)Wtsi/Cib2tm1a(EUCOMM)Wtsi
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Age:
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postnatal day 18
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Note:
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Triple labeled: green - Myosin VIIa (Myo7a); cyan - alpha-acetylated tubulin; red - phalloidin.
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Analysis Tools