Cib2^tm1.1Zma
Targeted Allele Detail

Summary

• Symbol: Cib2^tm1.1Zma
• Name: calcium and integrin binding family member 2; targeted mutation 1.1, Zubair M Ahmed
• MGI ID: MGI:6721389
• Synonyms: Cib2^F91S
• Gene: Cib2 Location: Chr9:54452078-54467502 bp, - strand Genetic Position: Chr9, 29.7 cM
• Alliance: Cib2^tm1.1Zma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244562
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct modified exon 4 with the point mutation (c.272 T to C; ENSMUST00000041901) that results in the amino acid substitution of phenylalanine with serine. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 4. (J:244562)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cib2 Mutation: 15 strains or lines available

References

• Original: J:244562 Giese APJ, et al., CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017 Jun 29;8(1):43
• All: 1 reference(s)