Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cluem1.1(cre/ERT2)Algr
Name:	clusterin; endonuclease-mediated mutation 1, Alex Gregorieff
MGI ID:	MGI:6716263
Synonyms:	Clucre-ERT2
Gene:	Clu  Location: Chr14:66205932-66218996 bp, + strand  Genetic Position: Chr14, 34.36 cM
Alliance:	Cluem1.1(cre/ERT2)Algr page

Germline Transmission:	Earliest citation of germline transmission: J:283362
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Cluem1.1(cre/ERT2)Algr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Clu (MGI:88423)   Mutation details: The allele was created by inserting the cre/ERT2 cassette at the translation start site of the mouse Clu locus in R1 ES cells using CRISPRCas9-mediated homologous recombination. The neomycin cassette was removed by crossing Clucre-ERT2 mice with Flp recombinase-expressing mice. (J:283362)

Activity:	Tissue activity of this recombinase allele
Driver:	Clu (mouse) Summary of all recombinase alleles driven by Clu. Comparative matrix view of recombinase activities Alliance mouse Clu gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clu Mutation:	31 strains or lines available

Original:	J:283362 Ayyaz A, et al., Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature. 2019 May;569(7754):121-125
All:	2 reference(s)