About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:100909 Vasyutina E, et al., CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005 Sep 15;19(18):2187-98
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6491874
Gene symbol: Lbx1
Gene name: ladybird homeobox 1
Antibody: anti-Lbx1
Results
Specimen 1C: embryonic day 10.0; Lbx1tm2Cbm/Lbx1+ (more )
Note: Double labeled: red - Lbx1 protein; green - Lbx1 reporter (assay MGI:6491872).
Structure Level Pattern Image Note
TS16: forelimb bud mesenchyme Present Regionally restricted 1C Expression in migrating muscle progenitors of dorsal and ventral limb.

Specimen 2G: embryonic day 10.25 (more )
Note: Double labeled: green - Lbx1; red - Cxcr4 (assay MGI:6491875).
Structure Level Pattern Image Note
TS17: mesenchyme derived from somites 01-04 Present Regionally restricted 2G Co-expression with Cxcr4 xpression in muscle progenitors migrating along hypoglossal cord and in muscle progenitors in tongue anlage.
TS17: 1st branchial arch mesenchyme derived from head mesoderm Present Regionally restricted 2G Expression in muscle progenitors colonizing mesenchyme of first branchial arch.

Specimen 3A: embryonic day 10.25 (more )
Note: Double labeled: green - Lbx1; red - Cxcr4 (assay MGI:6491875).
Structure Level Pattern Image Note
TS17: dermomyotome Present Regionally restricted 3A Expression in progenitors prior to delamination from ventrolateral dermomyotome. Co-expression with Cxcr4 only after migrating progenitors cells have moved away from the dermomyotome.
TS17: forelimb bud mesenchyme Present Regionally restricted 3A Co-expression with Cxcr4 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1, but not every Lbx1-expressing cell expresses Cxcr4.

Specimen 3B: embryonic day 10.75 (more )
Note: Double labeled: green - Lbx1; red - Cxcr4 (assay MGI:6491875).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 3B Co-expression with Cxcr4 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1, but not every Lbx1-expressing cell expresses Cxcr4.

Specimen 3C: embryonic day 11.25 (more )
Note: Double labeled: green - Lbx1; red - Cxcr4 (assay MGI:6491875).
Structure Level Pattern Image Note
TS19: forelimb bud mesenchyme Present Regionally restricted 3C Co-expression with Cxcr4 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1, but not every Lbx1-expressing cell expresses Cxcr4.

Specimen 3D: embryonic day 10.25 (more )
Note: Double labeled: green - Lbx1; red - Cxcr4 (assay MGI:6491875).
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 3D Expression in all Cxcr4-expressing muscle progenitor cell, but not expressed in all Cxcr4-expressing cells.

Specimen 5A: embryonic day 10.75; Cxcr4tm1Qma/Cxcr4+ (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: mesenchyme derived from somites 01-04 Present Regionally restricted 5A Expression in stream of muscle progenitors along hypoglossal cord.
TS18: 1st branchial arch mesenchyme derived from head mesoderm Present Regionally restricted 5A Expression in muscle progenitors colonizing mesenchyme of first branchial arch.

Specimen 5B: embryonic day 10.75; Cxcr4tm1Qma/Cxcr4tm1Qma (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: 1st branchial arch mesenchyme derived from head mesoderm Present Regionally restricted 5B Number of expressing muscle progenitor cells in first branchial arch reduced compared to control.

Specimen 5C: embryonic day 10.75; Gab1tm1Wbm/Gab1tm1Wbm (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: 1st branchial arch mesenchyme derived from head mesoderm Present Regionally restricted 5C Number of expressing muscle progenitor cells in first branchial arch reduced compared to control.

Specimen 5D: embryonic day 10.75; Cxcr4tm1Qma/Cxcr4tm1Qma, Gab1tm1Wbm/Gab1tm1Wbm (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: 1st branchial arch mesenchyme derived from head mesoderm Absent 5D Authors report absence of muscle progenitors in first branchial arch.

Specimen not shown: embryonic day 11.5; Cxcr4tm1Qma/Cxcr4tm1Qma, Gab1tm1Wbm/Gab1tm1Wbm (more )
Structure Level Pattern Image Note
TS19: branchial arch mesenchyme derived from head mesoderm Absent Authors report absence of muscle progenitors in first branchial arch.

Specimen 6A: embryonic day 10.75; Cxcr4tm1Qma/Cxcr4+ (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 6A Expression in muscle progenitor cells.

Specimen 6B: embryonic day 10.75; Cxcr4tm1Qma/Cxcr4tm1Qma (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 6B Reduction in number of expressing cells compared to control embryos, more pronounced in distal than in proximal domain of dorsal limb.

Specimen 6C: embryonic day 10.75; Gab1tm1Wbm/Gab1tm1Wbm (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 6C Expression in muscle progenitor cells.

Specimen 6D: embryonic day 10.75; Cxcr4tm1Qma/Cxcr4tm1Qma, Gab1tm1Wbm/Gab1tm1Wbm (more )
Note: Double labeled: red - Lbx1; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 6D In dorsal and ventral limb, number of expressing cells further reduced compared to Gab1-/- mutant embryos.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory