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Gene Expression Data
Assay Details
Assay
Reference: J:100909 Vasyutina E, et al., CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005 Sep 15;19(18):2187-98
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6491875
Gene symbol: Cxcr4
Gene name: C-X-C motif chemokine receptor 4
Antibody: anti-Cxcr4
Results
Specimen 2G: embryonic day 10.25 (more )
Note: Double labeled: red - Cxcr4; green - Lbx1 (assay MGI:6491874).
Structure Level Pattern Image Note
TS17: mesenchyme derived from somites 01-04 Present Regionally restricted 2G Co-expression with Lbx1 in muscle progenitors migrating along hypoglossal cord and in muscle progenitors in tongue anlage.
TS17: 1st branchial arch mesenchyme derived from head mesoderm Present Regionally restricted 2G Expression in first branchial arch. Expression in most but not all Lbx1-expressing cells.

Specimen 3A: embryonic day 10.25 (more )
Note: Double labeled: red - Cxcr4; green - Lbx1 (assay MGI:6491874).
Structure Level Pattern Image Note
TS17: dermomyotome Absent 3A No expression in ventral dermomyotomal lip, delaminating Lbx1-expressing cells or myotome. Co-expression with Lbx1 only after migrating progenitors cells have moved away from the dermomyotome.
TS17: myotome Absent 3A No expression in ventral dermomyotomal lip, delaminating Lbx1-expressing cells or myotome. Co-expression with Lbx1 only after migrating progenitors cells have moved away from the dermomyotome.
TS17: forelimb bud mesenchyme Present Regionally restricted 3A Co-expression with Lbx1 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1. Expression in subpopulation of Lbx1-expressing cells located close to ectoderm.
TS17: forelimb bud Present Regionally restricted 3A Expression in limb endothelial cells.

Specimen 3B: embryonic day 10.75 (more )
Note: Double labeled: red - Cxcr4; green - Lbx1 (assay MGI:6491874).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 3B Co-expression with Lbx1 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1. Expression in subpopulation of Lbx1-expressing cells located close to ectoderm. Significant number of Lbx1-expressing cells remain negative for Cxcr4 expression.

Specimen 3C: embryonic day 11.25 (more )
Note: Double labeled: red - Cxcr4; green - Lbx1 (assay MGI:6491874).
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Present Regionally restricted 3C Co-expression with Lbx1 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1. Expression in subpopulation of Lbx1-expressing cells located close to ectoderm. Significant number of Lbx1-expressing cells remain negative for Cxcr4 expression.

Specimen 3D: embryonic day 10.25 (more )
Note: Double labeled: red - Cxcr4; green - Lbx1 (assay MGI:6491874).
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 3D Co-expression with Lbx1 in muscle masses. All Cxcr4-expressing cells in premuscle masses also expressing Lbx1. Expression in subpopulation of Lbx1-expressing cells located close to ectoderm.

Specimen 3E: embryonic day 10.25 (more )
Note: Double labeled: red - Cxcr4; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted 3E Rare co-expression with Myod1.

Specimen not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present Regionally restricted Authors state Cxcr4-expressing and Myod1-expressing cell populations are distinct at E10.25, E10.5 and E11.25.

Specimen 3F: embryonic day 11.25 (more )
Note: Double labeled: red - Cxcr4; green - Myod1 (assay MGI:6491876).
Structure Level Pattern Image Note
TS19: forelimb bud mesenchyme Present Regionally restricted 3F Rare co-expression with Myod1.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory