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Gene Expression Data
Assay Details
Assay
Reference: J:278136 Hertz NT, et al., Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. 2019 Aug 7;103(3):412-422.e4
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6477413
Gene symbol: Ntrk1
Gene name: neurotrophic tyrosine kinase, receptor, type 1
Results
Specimen 4A Casp3+/+ left: embryonic day 12.5 (more )
Note: Double labeled: aqua - Ntrk1; red - Casp3 (assay MGI:6477414).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A1 left Coexpressed with cleaved Casp3.
Specimen 4A Casp3-/- left: embryonic day 12.5; Casp3tm1Flv/Casp3tm1Flv (more )
Note: Double labeled: aqua - Ntrk1; red - Casp3 (assay MGI:6477414).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A2 left Cleaved Casp3 staining was lost compared with the wild-type.
Specimen 4A Rufty3+/+ left: embryonic day 12.5 (more )
Note: Double labeled: aqua - Ntrk1; red - Casp3 (assay MGI:6477414).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A3 left Coexpressed with cleaved Casp3.
Specimen 4A Rufty3-/- left: embryonic day 12.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Note: Double labeled: aqua - Ntrk1; red - Casp3 (assay MGI:6477414).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A4 left Cleaved Casp3 staining was reduced compared with the wild-type.
Specimen 4D left: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: ganglion Present Widespread 4D left
Specimen 4D right: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv (more )
Structure Level Pattern Image Note
TS22: ganglion Present Widespread 4D right Increased number in postive nerve bundles, compared with wild-type.
Specimen 4E left: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: ganglion Present Widespread 4E left
Specimen 4E right: embryonic day 14.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: ganglion Present Widespread 4E right Increased number in postive nerve bundles, compared with wild-type. More severe defasciculation phenotype than in the Casp3-/- mutant.
Specimen 4F Casp3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cranial ganglion Present 4F1 left
Specimen 4F Casp3-/-: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv (more )
Structure Level Pattern Image Note
TS22: cranial ganglion Present 4F1 right A rostrally located ganglion, Frorieps ganglion, was present abnormally.
Specimen 4F Rufty3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cranial ganglion Present 4F2 left
Specimen 4F Rufty3-/-: embryonic day 14.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: cranial ganglion Present 4F2 right A rostrally located ganglion, Frorieps ganglion, was present abnormally. Also displayed a pronounced defect in organization and fasciculation of positive axons.
Specimen 4F Casp3-/- Rufty3+/+: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv (more )
Structure Level Pattern Image Note
TS22: cranial ganglion Present 4F3 left A rostrally located ganglion, Frorieps ganglion, was present abnormally.
Specimen 4F Casp3-/- Rufty3-/-: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv, Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: cranial ganglion Present 4F3 right A rostrally located ganglion, Frorieps ganglion, was present abnormally. Also displayed a pronounced defect in organization and fasciculation of positive axons.
Specimen 4G Casp3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4G1 left
Specimen 4G Casp3-/-: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4G1 right Increased expression compared with wild-type.
Specimen 4G Rufty3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4G2 left
Specimen 4G Rufty3-/-: embryonic day 14.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4G2 right A pronounced defect in organization and fasciculation of positive axons proximal to the ganglions was seen.
Specimen 4G Casp3-/- Rufty3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4G3 left Increased expression compared with wild-type.
Specimen 4G Casp3-/- Rufty3-/-: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv, Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4G3 right A pronounced defect in organization and fasciculation of positive axons proximal to the ganglions was seen.
Specimen 4H Casp3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present Regionally restricted 4H1 left Expressed in the axons in the whisker pad.
Specimen 4H Casp3-/-: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present Regionally restricted 4H1 right Increased expression compared with wild-type.
Specimen 4H Rufty3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present Regionally restricted 4H2 left Expressed in the axons in the whisker pad.
Specimen 4H Rufty3-/-: embryonic day 14.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present Regionally restricted 4H2 right Increased expression compared with wild-type. Also displayed a pronounced defect in organization and fasciculation of positive axons.
Specimen 4H Casp3-/- Rufty3+/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present Regionally restricted 4H3 left Increased expression compared with wild-type.
Specimen 4H Casp3-/- Rufty3-/-: embryonic day 14.5; Casp3tm1Flv/Casp3tm1Flv, Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Present Regionally restricted 4H3 right Increased expression compared with wild-type. Also displayed a pronounced defect in organization and fasciculation of positive axons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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