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Gene Expression Data
Assay Details
Assay
Reference: J:278136 Hertz NT, et al., Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. 2019 Aug 7;103(3):412-422.e4
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6477414
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Assay notes: Data was summarized in Fig. 4B & 4C.
Results
Specimen 4A Casp3+/+ left: embryonic day 12.5 (more )
Note: Double labeled: red - Casp3; aqua - Ntrk1 (assay MGI:6477413).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A1 left
Specimen 4A Casp3-/- left: embryonic day 12.5; Casp3tm1Flv/Casp3tm1Flv (more )
Note: Double labeled: red - Casp3; aqua - Ntrk1 (assay MGI:6477413).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Absent 4A2 left
Specimen 4A Casp3+/+ right: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hand Present 4A1 right
Specimen 4A Casp3-/- right: embryonic day 12.5; Casp3tm1Flv/Casp3tm1Flv (more )
Structure Level Pattern Image Note
TS20: hand Absent 4A2 right
Specimen 4A Rufty3+/+ left: embryonic day 12.5 (more )
Note: Double labeled: red - Casp3; aqua - Ntrk1 (assay MGI:6477413).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A3 left
Specimen 4A Rufty3-/- left: embryonic day 12.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Note: Double labeled: red - Casp3; aqua - Ntrk1 (assay MGI:6477413).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present 4A4 left Reduced expression compared with the wild-type.
Specimen 4A Rufty3+/+ right: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hand Present 4A3 right
Specimen 4A Rufty3-/- right: embryonic day 12.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3tm1b(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS20: hand Present 4A4 right Similar expression compared with the wild-type.
Specimen not shown Casp+/-: embryonic day 12.5; Casp3tm1Flv/Casp3+ (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present Reduced expression compared with the wild-type.
TS20: hand Present No significant changes compared with the wild-type.
Specimen not shown Rufty3+/-: embryonic day 12.5; Rufy3tm1b(EUCOMM)Hmgu/Rufy3+ (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present Similar expression compared with the wild-type.
TS20: hand Present Similar expression compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory