Trp53 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:261042 Welcker D, et al., AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Mar;37(11):1503-1518
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6477314
Gene symbol:	Trp53
Gene name:	transformation related protein 53

Antibody:	anti-p53 (CM5, P53-PROTEIN-CM5)
Detection system:	Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase

Results

Specimen 2e K14^Cre-neg;Aatf^fl/fl: embryonic day 14.5; Aatf^tm1.1Rein/Aatf^tm1.1Rein (more

)

Structure	Level	Pattern	Image	Note
TS22: epidermis	Present	Regionally restricted	2e p53 K14^Cre-neg;Aatf^fl/fl	Control embryos displayed immunopositive proliferating epidermal cells juxtaposed to the basal membrane.

Specimen 2e K14^Cre;Aatf^fl/fl: embryonic day 14.5; Aatf^tm1.1Rein/Aatf^tm1.1Rein, Tg(KRT14-cre)1Cgn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: epidermis	Strong	Regionally restricted	2e p53 K14^Cre;Aatf^fl/fl	An increase in nuclear immunostaining was detected in the conditional mutant embryos.

Specimen S2c K14^Cre-neg;Aatf^fl/fl E16.5: embryonic day 16.5; Aatf^tm1.1Rein/Aatf^tm1.1Rein (more

)

Structure	Level	Pattern	Image	Note
TS24: epidermis	Present	Regionally restricted	S2c p53 E16.5 K14^Cre-neg;Aatf^fl/fl	Control embryos displayed immunopositive proliferating epidermal cells juxtaposed to the basal membrane.

Specimen S2c K14^Cre;Aatf^fl/fl E16.5: embryonic day 16.5; Aatf^tm1.1Rein/Aatf^tm1.1Rein, Tg(KRT14-cre)1Cgn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS24: epidermis	Strong	Regionally restricted	S2c p53 E16.5 K14^Cre;Aatf^fl/fl	An increase in nuclear immunostaining was detected in the conditional mutant embryos.

Specimen S2c K14^Cre-neg;Aatf^fl/fl E18.5: embryonic day 18.5; Aatf^tm1.1Rein/Aatf^tm1.1Rein (more

)

Structure	Level	Pattern	Image	Note
TS26: epidermis	Present	Regionally restricted	S2c p53 E18.5 K14^Cre-neg;Aatf^fl/fl	Control embryos displayed immunopositive proliferating epidermal cells juxtaposed to the basal membrane.

Specimen S2c K14^Cre;Aatf^fl/fl E18.5: embryonic day 18.5; Aatf^tm1.1Rein/Aatf^tm1.1Rein, Tg(KRT14-cre)1Cgn/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: epidermis	Strong	Regionally restricted	S2c p53 E18.5 K14^Cre;Aatf^fl/fl	An increase in nuclear immunostaining was detected in the conditional mutant embryos.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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