Aatf^tm1.1Rein
Targeted Allele Detail

Summary

• Symbol: Aatf^tm1.1Rein
• Name: apoptosis antagonizing transcription factor; targeted mutation 1.1, H Christian Reinhardt
• MGI ID: MGI:6297000
• Synonyms: Aatf^fl
• Gene: Aatf Location: Chr11:84313681-84404348 bp, - strand Genetic Position: Chr11, 51.3 cM, cytoband B5
• Alliance: Aatf^tm1.1Rein page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261042
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombincation removed the selection cassette. (J:261042)

Expression

In Mice Carrying this Mutation:

208084 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aatf Mutation: 40 strains or lines available

References

• Original: J:261042 Welcker D, et al., AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Mar;37(11):1503-1518
• All: 2 reference(s)