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Gene Expression Data
Assay Details
Assay
Reference: J:40784 Otto F, et al., Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997 May 30;89(5):765-71
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6466575
Gene symbol: Runx2
Gene name: runt related transcription factor 2
Reporter: lacZ
Direct Detection
Results
Specimen 4A: embryonic day 10.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS17: skeleton Present Regionally restricted 4A Expression is in the prospective shoulder region.
Specimen 4B: embryonic day 11.5; Runx2tm1Mjo/Runx2+ (more )
Structure Level Pattern Image Note
TS19: 1st branchial arch maxillary component Present 4B
TS19: mandible primordium Present 4B
TS19: future arm mesenchyme Present Regionally restricted 4B Expression is in the developing humerus.
TS19: pectoral-thoracic pre-cartilage condensation Present Regionally restricted 4B Expression is in the developing scapula.
Specimen 4C: embryonic day 12.5; Runx2tm1Mjo/Runx2+ (more )
Structure Level Pattern Image Note
TS20: limb mesenchyme Present Regionally restricted 4C Expression is in developing limb bone.
TS20: skeleton Present Regionally restricted 4C Expression is in developing limb bone.
TS20: jaw bone Present 4C
Specimen 4D: embryonic day 12.5; Runx2tm1Mjo/Runx2+ (more )
Note: Bisected embryo.
Structure Level Pattern Image Note
TS20: cranium Present 4D
TS20: rib pre-cartilage condensation Present 4D
TS20: vertebral cartilage condensation Present 4D
Specimen 4E: embryonic day 12.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS20: shoulder Present 4E
Specimen 4F: embryonic day 12.5; Runx2tm1Mjo/Runx2+ (more )
Structure Level Pattern Image Note
TS20: shoulder Present Regionally restricted 4F Expression is in the clavicle.
Specimen 4G: embryonic day 12.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS20: genital tubercle Present Regionally restricted 4G Expression is dorsal.
TS20: skeleton Present Regionally restricted 4G Expression is in the pelvic girdle.
Specimen 4H: embryonic day 12.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS20: radius-ulna pre-cartilage condensation Present Regionally restricted 4H Expression is in the periosteal mesenchyme.
Specimen 4I: embryonic day 12.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS20: mammary gland primordium Present Regionally restricted 4I Expression is in the nascent epithelium.
Specimen 4J: embryonic day 12.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS20: notochord Present 4J
TS20: axial skeleton Present Regionally restricted 4J Expression is in the nucleus pulposus throughout the length of the vertebral column.
Specimen not shown E9.5: embryonic day 9.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS15: notochord Weak Regionally restricted Expression is underlying the mid- and hindbrain.
Specimen not shown E10.5: embryonic day 10.5; Runx2tm1Mjo/Runx2tm1Mjo (more )
Structure Level Pattern Image Note
TS17: notochord Present Regionally restricted Expression extended posteriorly to the trunk region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory