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Gene Expression Data
Assay Details
Assay
Reference: J:263032 Magella B, et al., Reduced Abd-B Hox function during kidney development results in lineage infidelity. Dev Biol. 2018 Jun 15;438(2):84-93
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6457072
Gene symbol: Six2
Gene name: sine oculis-related homeobox 2
Antibody: anti-Six2 (11562-1-AP)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2 E14.5 WT: embryonic day 14.5 (more )
Note: Double labeled: green - Six2: red - Mafb (assay MGI:6457078).
Structure Level Pattern Image Note
TS22: cap mesenchyme Strong 2_upper left Expressed in nephron progenitor cells.
Specimen 2 E14.5 mut: embryonic day 14.5; Hoxatm1.1Ssp/Hoxatm1.1Ssp, Hoxdtm1.1Ssp/Hoxdtm1.1Ssp (more )
Note: Double labeled: green - Six2: red - Mafb (assay MGI:6457078).
Structure Level Pattern Image Note
TS22: cap mesenchyme Trace 2_upper right Precocious and severe reduction in number of positive stained nephron progenitors. Only very few nephron progenitors were seen.
Specimen 2 E16.5 WT: embryonic day 16.5 (more )
Note: Double labeled: green - Six2: red - Mafb (assay MGI:6457078).
Structure Level Pattern Image Note
TS24: cap mesenchyme Strong 2_lower left Expressed in nephron progenitor cells.
Specimen 2 E16.5 mut: embryonic day 16.5; Hoxatm1.1Ssp/Hoxatm1.1Ssp, Hoxdtm1.1Ssp/Hoxdtm1.1Ssp (more )
Note: Double labeled: green - Six2: red - Mafb (assay MGI:6457078).
Structure Level Pattern Image Note
TS24: cap mesenchyme Trace 2_lower right Rarely observed any remaining clusters of positive stained nephron progenitors.
Specimen not shown: embryonic day 11.5; Hoxatm1.1Ssp/Hoxatm1.1Ssp, Hoxdtm1.1Ssp/Hoxdtm1.1Ssp (more )
Structure Level Pattern Image Note
TS19: cap mesenchyme Present Regionally restricted Expressed in nephron progenitor cells, similar as in the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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