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Gene Expression Data
Assay Details
Assay
Reference: J:231833 Hashimoto R, et al., Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mech Dev. 2016 May;140:25-40
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6444832
Gene symbol: Sox9
Gene name: SRY (sex determining region Y)-box 9
Antibody: anti-Sox9
Results
Specimen 3A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: metencephalon basal plate Present Regionally restricted 3A Expression in entire neuroepithelium of ventral rhombomere 1 (r1) at E11.5.
Specimen 3B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: metencephalon basal plate Present Widespread 3B
Specimen 3C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: metencephalon basal plate Present Widespread 3C Expression in ventral rhombomere 1 (r1) not only in proliferative zones, but also in parenchymal cells.
Specimen 3D: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: metencephalon basal plate Present Regionally restricted 3D Expression in ventral rhombomere 1 (r1). Decreased width of expressing region in neuroepithelial cells. Dramatic increase in expression in parenchyma.
Specimen 3E: embryonic day 11.5 (more )
Note: Double labeled: purple - Sox9; green - Olig2 (assay MGI:6444829).
Structure Level Pattern Image Note
TS19: metencephalon basal plate Present Regionally restricted 3E Expression in ventral rhombomere 1 (r1) throughout neuroepithelium, including Olig2-expressing domain.
Specimen 3F: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: metencephalon basal plate Present Regionally restricted 3F Expression in ventral rhombomere 1 (r1) in oligodendrocyte progenitor cells in mantle zone in vicinity of Olig2 neuroepithelial (NE) domain.
Specimen 3I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebellum Present 3I
Specimen 3J: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebellum Present Widespread 3J Expression in cerebellum primordium not only in proliferative zones, but also in parenchymal cells.
Specimen 3K: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebellum Present Widespread 3K Expression in cerebellum primordium Decreased width of expressing region in neuroepithelial cells. Dramatic increase in expression in parenchyma.
Specimen 3L: embryonic day 12.5 (more )
Note: Double labeled: purple - Sox9; green - Pdgfra (assay MGI:6444828).
Structure Level Pattern Image Note
TS20: metencephalon basal plate Present Regionally restricted 3L Expression in oligodendrocyte progenitor cells (OPCs) in ventral rhombomere 1 (r1).
Specimen 3M: embryonic day 14.5 (more )
Note: Double labeled: purple - Sox9; green - Pdgfra (assay MGI:6444828).
Structure Level Pattern Image Note
TS22: metencephalon basal plate Present Regionally restricted 3M Expression in oligodendrocyte progenitor cells (OPCs) in ventral rhombomere 1 (r1).
Specimen 3N: postnatal day 7 (more )
Note: Double labeled: purple - Sox9; green - Mbp (assay MGI:6444833).
Structure Level Pattern Image Note
TS28: metencephalon basal plate Present Regionally restricted 3N Expression absent in mature oligodendrocytes in postnatal ventral rhombomere 1 (r1).
Specimen 3O: postnatal adult (more )
Note: Double labeled: purple - Sox9; green - Mbp (assay MGI:6444833).
Structure Level Pattern Image Note
TS28: metencephalon basal plate Present Regionally restricted 3O Expression absent in mature oligodendrocytes in postnatal ventral rhombomere 1 (r1).
Specimen 3P: embryonic day 16.5 (more )
Note: Double labeled: purple - Sox9; green - Pdgfra (assay MGI:6444828).
Structure Level Pattern Image Note
TS24: cerebellum Present Regionally restricted 3P Expression in oligodendrocyte progenitor cells (OPCs) in cerebellum.
Specimen 3Q: embryonic day 18.5 (more )
Note: Double labeled: purple - Sox9; green - Pdgfra (assay MGI:6444828).
Structure Level Pattern Image Note
TS26: cerebellum Present Regionally restricted 3Q Expression in oligodendrocyte progenitor cells (OPCs) in cerebellum.
Specimen 3R: postnatal day 7 (more )
Note: Double labeled: purple - Sox9; green - Mbp (assay MGI:6444833).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 3R Expression absent in mature oligodendrocytes in postnatal cerebellum.
Specimen 3S: postnatal adult (more )
Note: Double labeled: purple - Sox9; green - Mbp (assay MGI:6444833).
Structure Level Pattern Image Note
TS28: cerebellum Present Regionally restricted 3S Expression absent in mature oligodendrocytes in postnatal cerebellum.
Specimen 4A En1-Cre; Sox9+/+: embryonic day 11.5; En1tm2(cre)Wrst/En1+ (more )
Structure Level Pattern Image Note
TS19: metencephalon basal plate Present 4A En1-Cre; Sox9+/+
Specimen 4A En1-Cre; Sox9flox/flox: embryonic day 11.5; Sox9tm2Crm/Sox9tm2Crm, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: metencephalon basal plate Absent 4A En1-Cre; Sox9flox/flox Expression completely eliminated in ventral rhombomere 1 (r1) at E11.5.
Specimen 4B En1-Cre; Sox9+/+: embryonic day 18.5; En1tm2(cre)Wrst/En1+ (more )
Structure Level Pattern Image Note
TS26: cerebellum Present 4B En1-Cre; Sox9+/+
Specimen 4B En1-Cre; Sox9flox/flox: embryonic day 18.5; Sox9tm2Crm/Sox9tm2Crm, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cerebellum Absent 4B En1-Cre; Sox9flox/flox Expression completely eliminated in cerebellum at E18.5.
Specimen 8A E14.5: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: metencephalon basal plate Absent 8A E14.5 Expression undetectable at E14.5.
Specimen 8A E16.5: embryonic day 16.5; Sox9tm2Crm/Sox9tm2Crm, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: metencephalon basal plate Present Regionally restricted 8A E16.5 Increased number of expressing-cells during late embryogenesis.
Specimen 8A E18.5: embryonic day 18.5; Sox9tm2Crm/Sox9tm2Crm, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: metencephalon basal plate Present Regionally restricted 8A E18.5 Increased number of expressing-cells during late embryogenesis.
Specimen 8C Sox9: embryonic day 18.5; Sox9tm2Crm/Sox9tm2Crm, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: metencephalon basal plate Present Regionally restricted 8C Sox9 Expression in ventral rhombomere 1 (r1).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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