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Gene Expression Data
Assay Details
Assay
Reference: J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6444678
Gene symbol: Mirc35hg
Gene name: microRNA cluster 35, host gene
Reporter: lacZ
Direct Detection
Results
Specimen 3A: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3A Expression was detected in all photoreceptors in the outer nuclear layer.
TS28: retina ganglion cell layer Present Regionally restricted 3A Expression was in a subgroup of ganglion cells.
TS28: retina inner nuclear layer Present Punctate 3A
Specimen 3B: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3B Expression was detected in all photoreceptors in the outer nuclear layer.
TS28: retina inner nuclear layer Present Punctate 3B
Specimen 3C: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3C Expression was detected in all photoreceptors in the outer nuclear layer.
TS28: retina ganglion cell layer Present Regionally restricted 3C Expression was in a subgroup of ganglion cells.
TS28: retina inner nuclear layer Present Punctate 3C
Specimen 3D CT1: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Note: Retinal sections were harvested every 4 h in a circadian cycle. CT = Circadian Time.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3D CT1 X-Gal staining showed that the intensity of expression in photoreceptors followed a circadian rhythm, with peak expression at Circadian Time (CT)1.
Specimen 3D CT5: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Note: Retinal sections were harvested every 4 h in a circadian cycle. CT = Circadian Time.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3D CT5 X-Gal staining showed that the intensity of expression in photoreceptors followed a circadian rhythm.
Specimen 3D CT9: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Note: Retinal sections were harvested every 4 h in a circadian cycle. CT = Circadian Time.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3D CT9 X-Gal staining showed that the intensity of expression in photoreceptors followed a circadian rhythm.
Specimen 3D CT13: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Note: Retinal sections were harvested every 4 h in a circadian cycle. CT = Circadian Time.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3D CT13 X-Gal staining showed that the intensity of expression in photoreceptors followed a circadian rhythm, with lowest expression at Circadian Time (CT)13.
Specimen 3D CT17: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Note: Retinal sections were harvested every 4 h in a circadian cycle. CT = Circadian Time.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3D CT17 X-Gal staining showed that the intensity of expression in photoreceptors followed a circadian rhythm.
Specimen 3D CT21: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Note: Retinal sections were harvested every 4 h in a circadian cycle. CT = Circadian Time.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present 3D CT21 X-Gal staining showed that the intensity of expression in photoreceptors followed a circadian rhythm.
Specimen not shown: embryonic day 10.5; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS17: retina Absent
Specimen not shown: embryonic day 14.5; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS22: retina Absent
Specimen 3F E16.5: embryonic day 16.5; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS24: retina Absent 3F E16.5
Specimen 3F E18.5: embryonic day 18.5; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS26: retina Absent 3F E18.5
Specimen 3F P1: postnatal day 1; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS27: retina Absent 3F P1
Specimen 3F P2: postnatal day 2; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS27: retina layer Present Regionally restricted 3F P2 Expression was detected in the outer neuroblast layer.
Specimen 3F P5: postnatal day 5; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Strong Regionally restricted 3F P5 At P5, ~40% of photoreceptors are still in the inner nuclear layer and are X-Gal-positive.
TS28: retina outer nuclear layer Strong 3F P5 Expression was drastically up-regulated at P5.
Specimen 3F P10: postnatal day 10; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Strong 3F P10 Expression was up-regulated further at P10 compared to P5.
TS28: retina outer nuclear layer Strong 3F P10 Expression was up-regulated further at P10 compared to P5.
Specimen 3F adult: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Strong 3F adult
TS28: retina inner nuclear layer Strong Punctate 3F adult
Specimen 4Aa: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: inner ear epithelium Present 4Aa
Specimen 4Ab: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present 4Ab
Specimen 4Ac: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: crista ampullaris Present 4Ac
TS28: saccule epithelium Present 4Ac
TS28: utricle epithelium Present 4Ac
Specimen 4B: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: olfactory epithelium Present 4B
TS28: vomeronasal organ Present 4B
Specimen 4C: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Present 4C , 4Ca
TS28: pineal gland Present 4C , 4Cb
Specimen 4D: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: circumvallate papillae Present 4Da , 4D
TS28: foliate papillae Present 4Dc , 4D , 4Db
TS28: fungiform papillae Present 4D , 4Dd
Specimen 4Ea: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: cervical dorsal root ganglion Present 4Ea
TS28: thoracic dorsal root ganglion Present 4Ea
Specimen 4Eb: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: lumbar dorsal root ganglion Present 4Eb
TS28: thoracic dorsal root ganglion Present 4Eb
Specimen S11A: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: inner ear epithelium Present S11A
Specimen S11B: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present S11B
Specimen S11C: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: crista ampullaris Present S11C
TS28: saccule epithelium Present S11C
TS28: utricle epithelium Present S11C
Specimen S11D: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: organ of Corti Present S11D
Specimen S11E: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: utricle epithelium Present S11E
Specimen S11F: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: saccule epithelium Present S11F
Specimen S11G: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: crista ampullaris Present S11G
Specimen S12A: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: circumvallate papillae Present S12Aa , S12A
TS28: foliate papillae Present S12Ac , S12Ab , S12A
TS28: fungiform papillae Present S12A , S12Ad
Specimen S12B: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: circumvallate papillae Present S12B
TS28: taste bud Present S12B
Specimen S13A: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: cervical dorsal root ganglion Present S13A
TS28: thoracic dorsal root ganglion Present S13A
Specimen S13B: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: lumbar dorsal root ganglion Present S13B
TS28: thoracic dorsal root ganglion Present S13B
Specimen S13C: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present S13C Expression was detected in primary sensory neurons.
Specimen S14A: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Present S14B , S14A
TS28: pineal gland Present S14C , S14A
Specimen S14D: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Present S14D , S14E
Specimen S14F: postnatal adult; Mirc35hgGt(D016D06)Wrst/Mirc35hg+ (more )
Structure Level Pattern Image Note
TS28: pineal gland Present S14F , S14G
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory