Klf2 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:287334 Wunnemann F, et al., Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet. 2020 Jan;52(1):40-47
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6437234
Gene symbol:	Klf2
Gene name:	Kruppel-like transcription factor 2 (lung)

Antibody:	anti-Klf2 (sc-28675)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

Specimen 6e +/+: postnatal week 3 (more

)

Structure	Level	Pattern	Image	Note
TS28: aortic valve	Ambiguous		6E +/+	This specimen was not discussed.

Specimen 6e KO/KO: postnatal week 3; Adamts19^{tm4b(EUCOMM)Wtsi}/Adamts19^{tm4b(EUCOMM)Wtsi} (more

)
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.

Structure	Level	Pattern	Image	Note
TS28: aortic valve	Present		6E KO/KO	Staining is increased in 4 out of 11 (36%) mutants.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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