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Gene Expression Data
Assay Details
Assay
Reference: J:242313 Forge A, et al., Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017 Mar;13(3):e1006692
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6414874
Gene symbol: Gpsm2
Gene name: G-protein signalling modulator 2 (AGS3-like, C. elegans)
Antibody: anti-LGN
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 11A normal: postnatal day 1 (more )
Note: Littermate control; mouse might carry the Cre transgene. Double labeled: green - Gpsm2 (LGN); red - actin.
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 11A , 11A' Expression localised to the surface of the outer and inner hair cells, specifically at the lateral pole. It is also seen at the tips of the longest stereocilia of outer hair cells.
Specimen 11B affected: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Gpsm2 (LGN); red - actin
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 11B , 11B' Expression is limited to the peri-centriolar region of some inner hair cells of affected animals.
Specimen 12A normal: postnatal day 1 (more )
Note: Littermate control; mouse might carry the Cre transgene. Double labeled: green - Gpsm2 (LGN); red - actin.
Structure Level Pattern Image Note
TS27: macula of utricle Present Regionally restricted 12A' , 12A Expression is seen in the hair cells, in a lateral compartment on the apical surface.
Specimen 12B affected: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Gpsm2 (LGN); red - actin
Structure Level Pattern Image Note
TS27: macula of utricle Absent 12B' , 12B No expression is seen in hair cells.
Specimen 13A normal: postnatal day 1 (more )
Note: Littermate control; mouse might carry the Cre transgene. Double labeled: green - Gpsm2 (LGN); red - actin.
Structure Level Pattern Image Note
TS27: crista ampullaris Present Regionally restricted 13A' , 13A Expression is seen on the surface of hair cells, especially on one side.
Specimen 13B affected: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Gpsm2 (LGN); red - actin
Structure Level Pattern Image Note
TS27: crista ampullaris Absent 13B' , 13B No expression is seen in hair cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory