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Gene Expression Data
Assay Details
Assay
Reference: J:203431 Collette NM, et al., Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 1;383(1):90-105
Assay type: RNA in situ
MGI Accession ID: MGI:6406358
Gene symbol: Grem1
Gene name: gremlin 1, DAN family BMP antagonist
Probe: Grem1 probe10
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 6B WT left: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B WT left Expression absent in region expressing Shh.
Specimen 6B WT right: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B WT right Expression absent in region expressing Shh.
Specimen 6B Sost-/- left: embryonic day 10.5; Sosttm1Paz/Sosttm1Paz (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B Sost-/- left Expression domain reduced on posterior side of limb bud.
Specimen 6B Sost-/- right: embryonic day 10.5; Sosttm1Paz/Sosttm1Paz (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B Sost-/- right Expression domain reduced on posterior side of limb bud.
Specimen 6B Sostdc1-/- left: embryonic day 10.5; Gli3Xt-J/Gli3+ (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B Sostdc1-/- left
Specimen 6B Sostdc1-/- right: embryonic day 10.5; Gli3Xt-J/Gli3+ (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B Sostdc1-/- right
Specimen 6B Sost-/-;Sostdc1-/- left: embryonic day 10.5; Sosttm1Paz/Sosttm1Paz, Sostdc1tm1Myan/Sostdc1tm1Myan (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B Sost-/-;Sostdc1-/- left Expression domain reduced on posterior side of limb bud.
Specimen 6B Sost-/-;Sostdc1-/- right: embryonic day 10.5; Sosttm1Paz/Sosttm1Paz, Sostdc1tm1Myan/Sostdc1tm1Myan (more )
Structure Level Pattern Image Note
TS17: limb bud Present Regionally restricted 6B Sost-/-;Sostdc1-/- right Expression domain reduced on posterior side of limb bud.
Specimen 7G: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: limb bud Present Regionally restricted 7G
Specimen 7G': embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: limb bud Present Regionally restricted 7G'
Specimen 7G": embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: limb bud Present Regionally restricted 7G"
Specimen 7K: embryonic day 11.5; Sosttm1Paz/Sosttm1Paz, Sostdc1tm1Myan/Sostdc1tm1Myan (more )
Structure Level Pattern Image Note
TS19: limb bud Present Regionally restricted 7K Expression reduced in anterior mesenchyme relative to wild type.
Specimen 7K': embryonic day 11.5; Sosttm1Paz/Sosttm1Paz, Sostdc1tm1Myan/Sostdc1tm1Myan (more )
Structure Level Pattern Image Note
TS19: limb bud Present Regionally restricted 7K' Expression reduced in anterior mesenchyme relative to wild type.
Specimen 7K": embryonic day 11.5; Sosttm1Paz/Sosttm1Paz, Sostdc1tm1Myan/Sostdc1tm1Myan (more )
Structure Level Pattern Image Note
TS19: limb bud Present Regionally restricted 7K"
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory