Aldh1b1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:192460 Ioannou M, et al., ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013 Feb 1;374(1):153-63
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6405178
Gene symbol:	Aldh1b1
Gene name:	aldehyde dehydrogenase 1 family, member B1

Antibody:	anti-Aldh1b1
Detection system:	Alexa Fluor 488

Results

S2A ©

Specimen S2A: embryonic day 14.5 (more

)
Note: Triple labeled: green - ALDH1B1 protein; red - Aldh1b1 RNA (assay MGI:6405174); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present	Regionally restricted	S2A	All expressing cells also express Aldh1b1 RNA.

S2B ©

Specimen S2B: embryonic day 14.5 (more

)
Note: Triple labeled: green - ALDH1B1 protein; red - Aldh1b1 RNA (assay MGI:6405174); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS22: pancreas	Present	Regionally restricted	S2B	All expressing cells also express Aldh1b1 RNA.

1C ©

Specimen 1C: embryonic day 9.5 (more

)
Note: Double labeled: green - Aldh1b1; red - Pdx1 (assay MGI:6405176).

Structure	Level	Pattern	Image	Note
TS15: pancreas primordium dorsal bud	Present	Regionally restricted	1C	Authors report co-expression with Pdx1.

1E ©

Specimen 1E: embryonic day 9.5; Pdx1^tm1Macd/Pdx1^tm1Macd (more

)
Note: Double labeled: green - Aldh1b1; red - Pdx1 (assay MGI:6405176).

Structure	Level	Pattern	Image	Note
TS15: pancreas primordium dorsal bud	Absent		1E

1G ©

Specimen 1G: embryonic day 10.5 (more

)
Note: Double labeled: green - Aldh1b1; red - Pdx1 (assay MGI:6405176).

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium dorsal bud	Present	Regionally restricted	1G	Authors report continued co-expression with Pdx1.
TS17: pancreas primordium ventral bud	Present	Regionally restricted	1G	Authors report continued co-expression with Pdx1.

1I ©

Specimen 1I: embryonic day 10.5; Pdx1^tm1Macd/Pdx1^tm1Macd (more

)
Note: Double labeled: green - Aldh1b1; blue - Isl1 (assay MGI:6405198).

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium dorsal bud	Absent		1I
TS17: pancreas primordium ventral bud	Absent		1I

2A ©

2B ©

Specimen 2A/B: embryonic day 12.5 (more

)
Note: Double labeled: green - Aldh1b1; red - Cdh1 (assay MGI:6405191).

Structure	Level	Pattern	Image	Note
TS20: pancreas epithelium	Present	Regionally restricted	2A , 2B	Expression exclusively in epithelium in both tips and trunks of developing pancreas, stronger at tips. No expression in mesenchyme.

2C ©

2D ©

Specimen 2C/D: embryonic day 14.5 (more

)
Note: Double labeled: green - Aldh1b1; red - Nkx6-1 (assay MGI:6405217).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Present	Regionally restricted	2C , 2D	Expression exclusively in epithelium in both tips and trunks of developing pancreas, stronger at tips. Expression in most but not all trunk cells. No expression in mesenchyme.

2E ©

Specimen 2E: embryonic day 14.5 (more

)
Note: Double labeled: green - Aldh1b1; red - Cdh1 (assay MGI:6405191).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Present	Regionally restricted	2E	Expression in trunk cells.

2F ©

2G ©

Specimen 2F/G: embryonic day 14.5 (more

)
Note: Double labeled: green - Aldh1b1; red - Nkx6-1 (assay MGI:6405217).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Present	Regionally restricted	2F , 2G

2H ©

Specimen 2H: embryonic day 14.5; Neurog3^tm1Fgu/Neurog3^tm1Fgu (more

)
Note: Double labeled: green - Aldh1b1; red - Cdh1 (assay MGI:6405191).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Present	Regionally restricted	2H	No expression in trunk cells.

2I ©

2J ©

Specimen 2I/J: embryonic day 14.5; Neurog3^tm1Fgu/Neurog3^tm1Fgu (more

)
Note: Triple labeled: green - Aldh1b1; red - Cdh1 (assay MGI:6405191); blue - Neurog3 (assay MGI:6405220).

Structure	Level	Pattern	Image	Note
TS22: pancreas epithelium	Present	Regionally restricted	2J , 2I	No expression in trunk cells.

Specimen E16.5 not shown: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: pancreas epithelium	Present	Regionally restricted		Expression restricted at tips.

Specimen E18.5 not shown: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: pancreas	Absent			Authors report expression was completely abolished by the end of the gestation period.

6A ©

Specimen 6A: postnatal adult (more

)
Note: Triple labeled: green - Aldh1b1; red - Cdh1 (assay MGI:6405191); blue - DAPI

Structure	Level	Pattern	Image	Note
TS28: pancreas	Ambiguous		6A

6B ©

Specimen 6B: postnatal adult (more

)
Note: Triple labeled: green - Aldh1b1; red - Cdh1 (assay MGI:6405191); blue - DAPI

Structure	Level	Pattern	Image	Note
TS28: pancreas	Present	Single cells	6B	Expression persisted in rare elongated cells in adult pancreas.

6C ©

Specimen 6C: postnatal adult (more

)
Note: Triple labeled: green - Aldh1b1; red - PNA; blue - DAPI

Structure	Level	Pattern	Image	Note
TS28: pancreas	Present	Single cells	6C	Expression in rare cells that were positive for PNA.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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